Breach delivery: increased solute uptake points to a defective skin barrier in atopic dermatitis

W. H. Irwin McLean, Peter R. Hull

    Research output: Contribution to journalArticlepeer-review

    24 Citations (Scopus)

    Abstract

    Evidence is now emerging for enhanced penetration of chemical solutes into uninvolved skin of atopic dermatitis patients. Along with the recent discovery of prevalent null mutations in the gene encoding filaggrin, a protein essential for stratum corneum formation, these data point to an innate epidermal-barrier defect in atopy.
    Original languageEnglish
    Pages (from-to)8-10
    Number of pages3
    JournalJournal of Investigative Dermatology
    Volume127
    Issue number1
    DOIs
    Publication statusPublished - 2007

    Keywords

    • Dermatitis, Atopic
    • Humans
    • Intermediate Filament Proteins
    • Mutation
    • Permeability
    • Polyethylene Glycols
    • Skin

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