Breach delivery: increased solute uptake points to a defective skin barrier in atopic dermatitis

W. H. Irwin McLean; Peter R. Hull

doi:10.1038/sj.jid.5700609

Breach delivery: increased solute uptake points to a defective skin barrier in atopic dermatitis

W. H. Irwin McLean, Peter R. Hull

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Evidence is now emerging for enhanced penetration of chemical solutes into uninvolved skin of atopic dermatitis patients. Along with the recent discovery of prevalent null mutations in the gene encoding filaggrin, a protein essential for stratum corneum formation, these data point to an innate epidermal-barrier defect in atopy.

Original language	English
Pages (from-to)	8-10
Number of pages	3
Journal	Journal of Investigative Dermatology
Volume	127
Issue number	1
DOIs	https://doi.org/10.1038/sj.jid.5700609
Publication status	Published - 2007

Keywords

Dermatitis, Atopic
Humans
Intermediate Filament Proteins
Mutation
Permeability
Polyethylene Glycols
Skin

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10.1038/sj.jid.5700609

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title = "Breach delivery: increased solute uptake points to a defective skin barrier in atopic dermatitis",

abstract = "Evidence is now emerging for enhanced penetration of chemical solutes into uninvolved skin of atopic dermatitis patients. Along with the recent discovery of prevalent null mutations in the gene encoding filaggrin, a protein essential for stratum corneum formation, these data point to an innate epidermal-barrier defect in atopy.",

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AB - Evidence is now emerging for enhanced penetration of chemical solutes into uninvolved skin of atopic dermatitis patients. Along with the recent discovery of prevalent null mutations in the gene encoding filaggrin, a protein essential for stratum corneum formation, these data point to an innate epidermal-barrier defect in atopy.

KW - Dermatitis, Atopic

KW - Humans

KW - Intermediate Filament Proteins

KW - Mutation

KW - Permeability

KW - Polyethylene Glycols

KW - Skin

U2 - 10.1038/sj.jid.5700609

DO - 10.1038/sj.jid.5700609

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Breach delivery: increased solute uptake points to a defective skin barrier in atopic dermatitis

Abstract

Keywords

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