Breaking Bad

How Viruses Subvert the Cell Cycle

Ying Fan, Sumana Sanyal, Roberto Bruzzone (Lead / Corresponding author)

Research output: Contribution to journalReview article

3 Citations (Scopus)
85 Downloads (Pure)

Abstract

Interactions between the host and viruses during the course of their co-evolution have not only shaped cellular function and the immune system, but also the counter measures employed by viruses. Relatively small genomes and high replication rates allow viruses to accumulate mutations and continuously present the host with new challenges. It is therefore, no surprise that they either escape detection or modulate host physiology, often by redirecting normal cellular pathways to their own advantage. Viruses utilize a diverse array of strategies and molecular targets to subvert host cellular processes, while evading detection. These include cell-cycle regulation, major histocompatibility complex-restricted antigen presentation, intracellular protein transport, apoptosis, cytokine-mediated signaling, and humoral immune responses. Moreover, viruses routinely manipulate the host cell cycle to create a favorable environment for replication, largely by deregulating cell cycle checkpoints. This review focuses on our current understanding of the molecular aspects of cell cycle regulation that are often targeted by viruses. Further study of their interactions should provide fundamental insights into cell cycle regulation and improve our ability to exploit these viruses.

Original languageEnglish
Article number396
Pages (from-to)1-28
Number of pages28
JournalFrontiers in cellular and infection microbiology
Volume8
DOIs
Publication statusPublished - 19 Nov 2018

Fingerprint

Cell Cycle
Viruses
Antigen Presentation
Protein Transport
Humoral Immunity
Cell Cycle Checkpoints
Major Histocompatibility Complex
Immune System
Genome
Apoptosis
Cytokines
Mutation

Keywords

  • viruses
  • cell cycle
  • checkpoint
  • infection
  • life cycle
  • host-pathogen interactions
  • phosphorylation
  • degradation

Cite this

Fan, Y., Sanyal, S., & Bruzzone, R. (2018). Breaking Bad: How Viruses Subvert the Cell Cycle. Frontiers in cellular and infection microbiology, 8, 1-28. [396]. https://doi.org/10.3389/fcimb.2018.00396
Fan, Ying ; Sanyal, Sumana ; Bruzzone, Roberto. / Breaking Bad : How Viruses Subvert the Cell Cycle. In: Frontiers in cellular and infection microbiology. 2018 ; Vol. 8. pp. 1-28.
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Fan, Y, Sanyal, S & Bruzzone, R 2018, 'Breaking Bad: How Viruses Subvert the Cell Cycle', Frontiers in cellular and infection microbiology, vol. 8, 396, pp. 1-28. https://doi.org/10.3389/fcimb.2018.00396

Breaking Bad : How Viruses Subvert the Cell Cycle. / Fan, Ying; Sanyal, Sumana; Bruzzone, Roberto (Lead / Corresponding author).

In: Frontiers in cellular and infection microbiology, Vol. 8, 396, 19.11.2018, p. 1-28.

Research output: Contribution to journalReview article

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PY - 2018/11/19

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Fan Y, Sanyal S, Bruzzone R. Breaking Bad: How Viruses Subvert the Cell Cycle. Frontiers in cellular and infection microbiology. 2018 Nov 19;8:1-28. 396. https://doi.org/10.3389/fcimb.2018.00396