Breast cancer metastasizing to Jaw bones as the sole primary source: Systematic review

TY - JOUR

T1 - Breast cancer metastasizing to Jaw bones as the sole primary source

T2 - Systematic review

AU - Gupta, Sonia

AU - Aga, Nausheen

AU - Vanka, Aruna

AU - Shreevats, Ruchira

AU - Hassan, Muna Eisa Mohamed

AU - Matcheswala, Fatema

N1 - Publisher Copyright: © 2025 National Journal of Maxillofacial Surgery.

PY - 2025/8/30

Y1 - 2025/8/30

N2 - Breast cancer has been known for its high propensity of metastasis to unusual locations and the jaw bones are one among those sites. Numerous studies examining metastatic tumours to the oral region have been described in the literature. However, the analysis of Breast cancer metastasis to the jaw bones alone has been the subject of relatively few published research studies to date. This review was conducted to examine the published cases of metastasis to jaw bones from breast cancer as the sole primary source from 1954-2023. An electronic search of the published literature was performed without publication year limitation in PubMed/ Medline, Scopus, Google Scholar, Web of Science, Science direct and Embase databases, using mesh keywords like ('Breast cancer', OR 'Breast carcinoma'), AND ('Metastasis' OR 'Metastases'), And ('Jaw' OR 'Maxilla' OR 'Mandible' OR 'Temporomandibular joint' OR 'Condyle'). We also searched all related journals manually. The reference list of all articles was also checked. Our research revealed a total of 63 relevant papers with 74 patients. The mandible was more predominantly affected jaw than the maxilla. 20% of patients died with a mean survival time of 1.8 years. To conclude, Breast cancer metastasis to the jaw bones is a rare occurrence. Careful evaluation of more number of such cases is needed in order to raise awareness of these lesions and gain a better understanding of their characteristics.reful evaluation of such cases is needed to raise awareness of these lesions and gain a better understanding of their characteristics.

AB - Breast cancer has been known for its high propensity of metastasis to unusual locations and the jaw bones are one among those sites. Numerous studies examining metastatic tumours to the oral region have been described in the literature. However, the analysis of Breast cancer metastasis to the jaw bones alone has been the subject of relatively few published research studies to date. This review was conducted to examine the published cases of metastasis to jaw bones from breast cancer as the sole primary source from 1954-2023. An electronic search of the published literature was performed without publication year limitation in PubMed/ Medline, Scopus, Google Scholar, Web of Science, Science direct and Embase databases, using mesh keywords like ('Breast cancer', OR 'Breast carcinoma'), AND ('Metastasis' OR 'Metastases'), And ('Jaw' OR 'Maxilla' OR 'Mandible' OR 'Temporomandibular joint' OR 'Condyle'). We also searched all related journals manually. The reference list of all articles was also checked. Our research revealed a total of 63 relevant papers with 74 patients. The mandible was more predominantly affected jaw than the maxilla. 20% of patients died with a mean survival time of 1.8 years. To conclude, Breast cancer metastasis to the jaw bones is a rare occurrence. Careful evaluation of more number of such cases is needed in order to raise awareness of these lesions and gain a better understanding of their characteristics.reful evaluation of such cases is needed to raise awareness of these lesions and gain a better understanding of their characteristics.

KW - Breast cancer

KW - jawbones

KW - mandible

KW - maxilla

KW - metastasis

UR - https://www.scopus.com/pages/publications/105014719205

U2 - 10.4103/njms.njms_66_24

DO - 10.4103/njms.njms_66_24

M3 - Review article

C2 - 41019672

AN - SCOPUS:105014719205

SN - 0975-5950

VL - 16

SP - 220

EP - 232

JO - National Journal of Maxillofacial Surgery

JF - National Journal of Maxillofacial Surgery

IS - 2

ER -