Breath-figure polymer films with local microporosity controlled via spatio-thermal templating

M. J. Mullan, P. A. Campbell

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    3 Citations (Scopus)

    Abstract

    Porous structures offer a vast range of important industrial applications. In the context of medicine, and specifically in the area of controlled drug delivery, spatial [and temporal] control over local porosity has a significant influence on net molecular flux through [membrane-based] controlled release platforms. Such systems may be formulated as oral, transdermal, or even implantable entities, and address chronic infusion needs covering such ailments as diabetes, cancer and hypertension [1]. In all the aforementioned situations, a facility to spatially control porosity could offer significant advantage, such as safer controlled release over extended durations. Here, we describe a novel route to engineering-in such flexibility within polymeric thin films by modifying spin-coating protocols to accommodate breath film patterning, that is, the spatially controlled condensation of pore forming droplets onto a liquid-polymer film. Upon film solidification, characterization via optical- and scanning probe microscopy revealed that local variations in porosity, as inferred from topographic measurements, could be effectively controlled through provision of an embossed vacuum holding chuck that effectively retains intimate thermal contact with the film substrate during forming. Parallel measurements using real time thermography support the hypothesis that porosity is controlled by local solvent evaporation rates.

    Original languageEnglish
    Title of host publication2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vols.1-8
    Place of PublicationNEW YORK
    PublisherIEEE Computer Society
    Pages2514-2517
    Number of pages4
    ISBN (Print)978-1-4244-1814-5
    DOIs
    Publication statusPublished - 2008
    Event30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Vancouver, Canada
    Duration: 20 Aug 200825 Aug 2008

    Conference

    Conference30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    CountryCanada
    CityVancouver
    Period20/08/0825/08/08

    Keywords

    • polymer
    • porous
    • breath figure
    • thermal imaging
    • drug delivery

    Cite this

    Mullan, M. J., & Campbell, P. A. (2008). Breath-figure polymer films with local microporosity controlled via spatio-thermal templating. In 2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vols.1-8 (pp. 2514-2517). NEW YORK: IEEE Computer Society. https://doi.org/10.1109/IEMBS.2008.4649711
    Mullan, M. J. ; Campbell, P. A. / Breath-figure polymer films with local microporosity controlled via spatio-thermal templating. 2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vols.1-8. NEW YORK : IEEE Computer Society, 2008. pp. 2514-2517
    @inproceedings{6eaf183d3e3646ad8009d485c0f3ad74,
    title = "Breath-figure polymer films with local microporosity controlled via spatio-thermal templating",
    abstract = "Porous structures offer a vast range of important industrial applications. In the context of medicine, and specifically in the area of controlled drug delivery, spatial [and temporal] control over local porosity has a significant influence on net molecular flux through [membrane-based] controlled release platforms. Such systems may be formulated as oral, transdermal, or even implantable entities, and address chronic infusion needs covering such ailments as diabetes, cancer and hypertension [1]. In all the aforementioned situations, a facility to spatially control porosity could offer significant advantage, such as safer controlled release over extended durations. Here, we describe a novel route to engineering-in such flexibility within polymeric thin films by modifying spin-coating protocols to accommodate breath film patterning, that is, the spatially controlled condensation of pore forming droplets onto a liquid-polymer film. Upon film solidification, characterization via optical- and scanning probe microscopy revealed that local variations in porosity, as inferred from topographic measurements, could be effectively controlled through provision of an embossed vacuum holding chuck that effectively retains intimate thermal contact with the film substrate during forming. Parallel measurements using real time thermography support the hypothesis that porosity is controlled by local solvent evaporation rates.",
    keywords = "polymer, porous, breath figure, thermal imaging, drug delivery",
    author = "Mullan, {M. J.} and Campbell, {P. A.}",
    year = "2008",
    doi = "10.1109/IEMBS.2008.4649711",
    language = "English",
    isbn = "978-1-4244-1814-5",
    pages = "2514--2517",
    booktitle = "2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vols.1-8",
    publisher = "IEEE Computer Society",

    }

    Mullan, MJ & Campbell, PA 2008, Breath-figure polymer films with local microporosity controlled via spatio-thermal templating. in 2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vols.1-8. IEEE Computer Society, NEW YORK, pp. 2514-2517, 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vancouver, Canada, 20/08/08. https://doi.org/10.1109/IEMBS.2008.4649711

    Breath-figure polymer films with local microporosity controlled via spatio-thermal templating. / Mullan, M. J.; Campbell, P. A.

    2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vols.1-8. NEW YORK : IEEE Computer Society, 2008. p. 2514-2517.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    TY - GEN

    T1 - Breath-figure polymer films with local microporosity controlled via spatio-thermal templating

    AU - Mullan, M. J.

    AU - Campbell, P. A.

    PY - 2008

    Y1 - 2008

    N2 - Porous structures offer a vast range of important industrial applications. In the context of medicine, and specifically in the area of controlled drug delivery, spatial [and temporal] control over local porosity has a significant influence on net molecular flux through [membrane-based] controlled release platforms. Such systems may be formulated as oral, transdermal, or even implantable entities, and address chronic infusion needs covering such ailments as diabetes, cancer and hypertension [1]. In all the aforementioned situations, a facility to spatially control porosity could offer significant advantage, such as safer controlled release over extended durations. Here, we describe a novel route to engineering-in such flexibility within polymeric thin films by modifying spin-coating protocols to accommodate breath film patterning, that is, the spatially controlled condensation of pore forming droplets onto a liquid-polymer film. Upon film solidification, characterization via optical- and scanning probe microscopy revealed that local variations in porosity, as inferred from topographic measurements, could be effectively controlled through provision of an embossed vacuum holding chuck that effectively retains intimate thermal contact with the film substrate during forming. Parallel measurements using real time thermography support the hypothesis that porosity is controlled by local solvent evaporation rates.

    AB - Porous structures offer a vast range of important industrial applications. In the context of medicine, and specifically in the area of controlled drug delivery, spatial [and temporal] control over local porosity has a significant influence on net molecular flux through [membrane-based] controlled release platforms. Such systems may be formulated as oral, transdermal, or even implantable entities, and address chronic infusion needs covering such ailments as diabetes, cancer and hypertension [1]. In all the aforementioned situations, a facility to spatially control porosity could offer significant advantage, such as safer controlled release over extended durations. Here, we describe a novel route to engineering-in such flexibility within polymeric thin films by modifying spin-coating protocols to accommodate breath film patterning, that is, the spatially controlled condensation of pore forming droplets onto a liquid-polymer film. Upon film solidification, characterization via optical- and scanning probe microscopy revealed that local variations in porosity, as inferred from topographic measurements, could be effectively controlled through provision of an embossed vacuum holding chuck that effectively retains intimate thermal contact with the film substrate during forming. Parallel measurements using real time thermography support the hypothesis that porosity is controlled by local solvent evaporation rates.

    KW - polymer

    KW - porous

    KW - breath figure

    KW - thermal imaging

    KW - drug delivery

    U2 - 10.1109/IEMBS.2008.4649711

    DO - 10.1109/IEMBS.2008.4649711

    M3 - Conference contribution

    SN - 978-1-4244-1814-5

    SP - 2514

    EP - 2517

    BT - 2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vols.1-8

    PB - IEEE Computer Society

    CY - NEW YORK

    ER -

    Mullan MJ, Campbell PA. Breath-figure polymer films with local microporosity controlled via spatio-thermal templating. In 2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vols.1-8. NEW YORK: IEEE Computer Society. 2008. p. 2514-2517 https://doi.org/10.1109/IEMBS.2008.4649711