Broad spectrum and safety of oral treatment with a promising nitrosylated chalcone in murine leishmaniasis

Ariane J. Sousa-Batista, Douglas Escrivani-Oliveira, Camila Alves Bandeira Falcão, Cintia Iana Monteiro da Silva Philipon, Bartira Rossi-Bergmann (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

The oral efficacy and safety of a leishmanicidal nitrochalcone (CH8) were studied in BALB/c mouse infections with Leishmania amazonensis and Leishmania infantum. Although 10-fold-higher doses of CH8 were needed to produce the same antiparasitic effect as that seen with the reference drug miltefosine, the latter was nephrotoxic, whereas CH8 restored disease toxicity markers to normal. This study shows the therapeutic potential of an orally active and hepato-/nephroprotective chalcone against cutaneous and visceral leishmaniases.

Original languageEnglish
Article numbere00792
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume62
Issue number10
Early online date16 Jul 2018
DOIs
Publication statusPublished - Oct 2018

Keywords

  • Chalcone
  • Chemotherapy
  • Leishmaniasis

Fingerprint

Dive into the research topics of 'Broad spectrum and safety of oral treatment with a promising nitrosylated chalcone in murine leishmaniasis'. Together they form a unique fingerprint.

Cite this