TY - JOUR
T1 - Broad spectrum and safety of oral treatment with a promising nitrosylated chalcone in murine leishmaniasis
AU - Sousa-Batista, Ariane J.
AU - Escrivani-Oliveira, Douglas
AU - Alves Bandeira Falcão, Camila
AU - da Silva Philipon, Cintia Iana Monteiro
AU - Rossi-Bergmann, Bartira
N1 - Publisher Copyright:
© 2018 American Society for Microbiology.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2018/10
Y1 - 2018/10
N2 - The oral efficacy and safety of a leishmanicidal nitrochalcone (CH8) were studied in BALB/c mouse infections with Leishmania amazonensis and Leishmania infantum. Although 10-fold-higher doses of CH8 were needed to produce the same antiparasitic effect as that seen with the reference drug miltefosine, the latter was nephrotoxic, whereas CH8 restored disease toxicity markers to normal. This study shows the therapeutic potential of an orally active and hepato-/nephroprotective chalcone against cutaneous and visceral leishmaniases.
AB - The oral efficacy and safety of a leishmanicidal nitrochalcone (CH8) were studied in BALB/c mouse infections with Leishmania amazonensis and Leishmania infantum. Although 10-fold-higher doses of CH8 were needed to produce the same antiparasitic effect as that seen with the reference drug miltefosine, the latter was nephrotoxic, whereas CH8 restored disease toxicity markers to normal. This study shows the therapeutic potential of an orally active and hepato-/nephroprotective chalcone against cutaneous and visceral leishmaniases.
KW - Chalcone
KW - Chemotherapy
KW - Leishmaniasis
UR - http://www.scopus.com/inward/record.url?scp=85053878377&partnerID=8YFLogxK
U2 - 10.1128/AAC.00792-18
DO - 10.1128/AAC.00792-18
M3 - Article
C2 - 30012761
AN - SCOPUS:85053878377
SN - 0066-4804
VL - 62
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 10
M1 - e00792
ER -
