Broad spectrum and safety of oral treatment with a promising nitrosylated chalcone in murine leishmaniasis

TY - JOUR

T1 - Broad spectrum and safety of oral treatment with a promising nitrosylated chalcone in murine leishmaniasis

AU - Sousa-Batista, Ariane J.

AU - Escrivani-Oliveira, Douglas

AU - Alves Bandeira Falcão, Camila

AU - da Silva Philipon, Cintia Iana Monteiro

AU - Rossi-Bergmann, Bartira

N1 - Publisher Copyright: © 2018 American Society for Microbiology. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 2018/10

Y1 - 2018/10

N2 - The oral efficacy and safety of a leishmanicidal nitrochalcone (CH8) were studied in BALB/c mouse infections with Leishmania amazonensis and Leishmania infantum. Although 10-fold-higher doses of CH8 were needed to produce the same antiparasitic effect as that seen with the reference drug miltefosine, the latter was nephrotoxic, whereas CH8 restored disease toxicity markers to normal. This study shows the therapeutic potential of an orally active and hepato-/nephroprotective chalcone against cutaneous and visceral leishmaniases.

AB - The oral efficacy and safety of a leishmanicidal nitrochalcone (CH8) were studied in BALB/c mouse infections with Leishmania amazonensis and Leishmania infantum. Although 10-fold-higher doses of CH8 were needed to produce the same antiparasitic effect as that seen with the reference drug miltefosine, the latter was nephrotoxic, whereas CH8 restored disease toxicity markers to normal. This study shows the therapeutic potential of an orally active and hepato-/nephroprotective chalcone against cutaneous and visceral leishmaniases.

KW - Chalcone

KW - Chemotherapy

KW - Leishmaniasis

UR - https://www.scopus.com/pages/publications/85053878377

U2 - 10.1128/AAC.00792-18

DO - 10.1128/AAC.00792-18

M3 - Article

C2 - 30012761

AN - SCOPUS:85053878377

SN - 0066-4804

VL - 62

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 10

M1 - e00792

ER -