Bronchiectasis

Miguel Barbosa, James D. Chalmers (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)
20 Downloads (Pure)

Abstract

Bronchiectasis is a final common pathway of a wide variety of underlying conditions including infectious, autoimmune, allergic, genetic and inflammatory conditions. Patients experience a chronic disease with variable clinical symptoms and course, but most experience cough, sputum production and recurrent exacerbations. Symptoms of bronchiectasis lead to poor quality of life and exacerbations are the major driver of morbidity and mortality. Patients are often chronically infected with bacteria with the most common being Pseudomonas aeruginosa and Haemophilus influenzae. Treatment of bronchiectasis includes standardised testing to identify the underlying cause with targeted treatment if immune deficiency, allergic bronchopulmonary aspergillosis or non-tuberculous mycobacterial infection, for example, are identified. Airway clearance is the mainstay of therapy for patients with symptoms of cough and sputum production. Frequently exacerbating patients may benefit from long term antibiotic or mucoactive therapies. Bronchiectasis is a heterogeneous disease and increasingly precision medicine approaches are advocated to target treatments most appropriately and to limit the emergence of antimicrobial resistance.
Original languageEnglish
Article number104174
Number of pages50
JournalLa Presse Médicale
Volume52
Issue number3
Early online date30 Sept 2023
DOIs
Publication statusPublished - Sept 2023

Keywords

  • Bronchiectasis
  • infection
  • antibiotics
  • microbiology
  • Infection
  • Antibiotics
  • Microbiology

ASJC Scopus subject areas

  • General Medicine

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