Burden of pneumococcal community-acquired pneumonia in adults across Europe: A literature review

Antoni Torres (Lead / Corresponding author), Catia Cillóniz, Francesco Blasi, James D. Chalmers, Jacques Gaillat, Nathalie Dartois, Heinz-Josef Schmitt, Tobias Welte

Research output: Contribution to journalReview articlepeer-review

80 Citations (Scopus)


BACKGROUND: The burden of community-acquired pneumonia (CAP) caused by Streptococcus pneumoniae (pneumococcus) among adults in Europe is poorly defined.

METHODS: Structured searches of PubMed were conducted to identify the incidence of pneumococcal CAP among adults across Europe.

RESULTS: The overall incidence rates for CAP was 68-7000 per 100,000 and the incidence in hospitalised CAP cases of all causes was 16-3581 per 100,000. In general the incidence of CAP increased consistently with age. Available data indicated higher burdens of pneumococcal CAP caused in groups with more comorbidities. Most cases of pneumococcal CAP (30%-78%) were caused by serotypes covered by PCV13 vaccine; the incidence of PCV13-related pneumonia decreased after the introduction of childhood vaccination.

CONCLUSIONS: We observed a high burden adult pneumococcal CAP in Europe despite use of the 23-valent pneumococcal polysaccharide vaccine, particularly in elderly patients with comorbidities. CAP surveillance presented wide variations across Europe. Pneumococcal CAP has to be monitored very carefully due to the possible effect of current vaccination strategies.

Original languageEnglish
Pages (from-to)6-13
Number of pages8
JournalRespiratory Medicine
Early online date19 Feb 2018
Publication statusPublished - Apr 2018


  • Community-acquired pneumonia
  • Epidemiology
  • Europe
  • Incidence
  • Pneumococcal
  • Pneumococcal vaccines
  • Pneumonia
  • Streptococcus pneumoniae

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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