TY - JOUR
T1 - Butyrophilins
T2 - An emerging family of immune regulators
AU - Abeler-Dörner, Lucie
AU - Swamy, Mahima
AU - Williams, Gareth
AU - Hayday, Adrian C.
AU - Bas, Anna
PY - 2012/1/1
Y1 - 2012/1/1
N2 - Butyrophilins (Btns) and butyrophilin-like (Btnl) molecules are emerging as novel regulators of immune responses in mice and humans. Several clues point to their probable importance: many of the genes are located within the MHC; they are structurally related to B7-co-stimulatory molecules; they are functionally implicated in T cell inhibition and in the modulation of epithelial cell-T cell interactions; and they are genetically associated with inflammatory diseases. Nonetheless, initial immersion into the current literature can uncover confusion over even basic information such as gene names and expression patterns, and seemingly conflicting data regarding the biological activities of different family members. This review addresses each of these issues, concluding with the attractive potential of Btn and Btnl molecules to act as specific attenuators of tissue-associated inflammatory responses.
AB - Butyrophilins (Btns) and butyrophilin-like (Btnl) molecules are emerging as novel regulators of immune responses in mice and humans. Several clues point to their probable importance: many of the genes are located within the MHC; they are structurally related to B7-co-stimulatory molecules; they are functionally implicated in T cell inhibition and in the modulation of epithelial cell-T cell interactions; and they are genetically associated with inflammatory diseases. Nonetheless, initial immersion into the current literature can uncover confusion over even basic information such as gene names and expression patterns, and seemingly conflicting data regarding the biological activities of different family members. This review addresses each of these issues, concluding with the attractive potential of Btn and Btnl molecules to act as specific attenuators of tissue-associated inflammatory responses.
UR - http://www.scopus.com/inward/record.url?scp=84855332652&partnerID=8YFLogxK
U2 - 10.1016/j.it.2011.09.007
DO - 10.1016/j.it.2011.09.007
M3 - Review article
C2 - 22030238
AN - SCOPUS:84855332652
VL - 33
SP - 34
EP - 41
JO - Trends in Immunology
JF - Trends in Immunology
SN - 1471-4906
IS - 1
ER -