C-MYC translocation in t(14;18) positive follicular lymphoma at presentation: An adverse prognostic indicator?

Lesley Christie, Neil Kernohan, David Levison, Mark Sales, Joan Cunningham, Karen Gillespie, Paul Batstone, David Meiklejohn, John Goodlad

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    Abstract

    Follicular lymphoma (FL) is a common subtype of low grade B-cell non-Hodgkin lymphoma (NHL). Although this form of lymphoma often pursues an indolent course, in some cases it may behave in a more aggressive manner. Clinical and histological parameters have been shown to correlate with an adverse prognosis but a number of cytogenetic abnormalities may also be associated with aggressive disease. Although, the t(14;18) in itself does not affect outcome in cases of FL, secondary abnormalities that occur in a complex polyploid karyotype may identify cases with a poor prognosis. It is unusual to find both t(14;18) and C-MYC translocation in the same tumour; those cases in which it has been described include examples of high-grade B-cell NHL (either de novo or transformed FL) or B-cell acute lymphoblastic lymphoma. In this report, three cases of FL are described in which both t(14;18) and a C-MYC translocation were identified at presentation. We also summarize four further cases from the literature. This is a small series but one which raises the possibility that the presence of a C-MYC translocations at presentation may identify a particularly aggressive subtype of FL. Further studies are required to investigate the true incidence of this aberration, the impact on C-MYC regulation, clinical course and response to treatment.

    Original languageEnglish
    Pages (from-to)470-476
    Number of pages7
    JournalLeukemia & Lymphoma
    Volume49
    Issue number3
    DOIs
    Publication statusPublished - 2008

    Keywords

    • lymphoma
    • prognostication
    • cytogenetics
    • NON-HODGKINS-LYMPHOMA
    • LARGE-CELL LYMPHOMA
    • ACUTE LYMPHOBLASTIC-LEUKEMIA
    • CHROMOSOMAL-ABNORMALITIES
    • PREDICTIVE MODEL
    • LOW-GRADE
    • TRANSFORMATION
    • GENE
    • T(14-18)
    • SURVIVAL

    Cite this

    Christie, L., Kernohan, N., Levison, D., Sales, M., Cunningham, J., Gillespie, K., Batstone, P., Meiklejohn, D., & Goodlad, J. (2008). C-MYC translocation in t(14;18) positive follicular lymphoma at presentation: An adverse prognostic indicator? Leukemia & Lymphoma, 49(3), 470-476. https://doi.org/10.1080/10428190701836845