C-type natriuretic peptide

Craig S. Barr, Peter Rhodes, Allan D. Struthers

    Research output: Contribution to journalArticlepeer-review

    125 Citations (Scopus)

    Abstract

    C-type natriuretic peptide is a 22-amino acid peptide that was initially identified in the central nervous system. The distribution of C-type natriuretic peptide, which has structural homology with atrial and brain natriuretic peptides, is wide and includes the endothelium, myocardium, gastrointestinal, and genitourinary tracts. The biological effects of this peptide are being elucidated in a number of sites in a number of species; however, the novel endothelial site of production of C-type natriuretic peptide and the proximal situation of its receptor in vascular smooth muscle suggest that this vascular natriuretic peptide system may play a role in concert with other local systems in the control of vascular tone.
    Original languageEnglish
    Pages (from-to)1243-1251
    Number of pages9
    JournalPeptides
    Volume17
    Issue number7
    DOIs
    Publication statusPublished - 1996

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