Ca2+ signalling in the control of motility and guidance in mammalian sperm

Stephen John Publicover (Lead / Corresponding author), Laura Cecilia Giojalas, Maria Eugenia Teves, Gisela Sofia Mendes Machado de Oliveira, Aduen Andres Morales Garcia, Christopher Lowther Robert Barratt, Claire Victoria Harper

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    100 Citations (Scopus)


    Ca2+ signalling in the sperm plays a key role in the regulation of events preceding fertilisation. Control of motility, including hyperactivation and chemotaxis, is particularly dependent upon [Ca2+](i) signalling in the principal piece of the flagellum and the midpiece. Here we briefly review the processes that contribute to regulation of [Ca2+](i) in mammalian sperm and then examine two areas: (i) the regulation of hyperactivation by [Ca2+](i) and the pivotal roles played by CatSpers (sperm-specific, Ca2+-permeable membrane channels) and intracellular Ca2+ stores in this process and (ii) the elevation of [Ca2+](i) and consequent modulation of motility caused by progesterone including the ability of progesterone at micromolar concentrations to cause sperm hyperactivation and/or accumulation and the recent discovery that progesterone, at picomolar concentrations, acts as a chemoattractant for mammalian sperm.

    Original languageEnglish
    Article number3105
    Pages (from-to)5623-5637
    Number of pages15
    JournalFrontiers in Bioscience-Landmark
    Publication statusPublished - 2008


    • Sperm
    • Calcium
    • Motility
    • Hyperactivation
    • Chemotaxis
    • Progesterone
    • CatSper
    • Calcium store
    • Ryanodine receptor
    • Review
    • Inositol 1,4,5-Trisphosphate receptor
    • Secretory pathway CA2+ atpase
    • Dependent calcium channels
    • Sea urchin spermatozoa
    • Catsper2 null sperm
    • Mouse sperm
    • Hyperactivated motility
    • Intracellular CA2+
    • Zona pellucida


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