Abstract
Ca2+ signalling in the sperm plays a key role in the regulation of events preceding fertilisation. Control of motility, including hyperactivation and chemotaxis, is particularly dependent upon [Ca2+](i) signalling in the principal piece of the flagellum and the midpiece. Here we briefly review the processes that contribute to regulation of [Ca2+](i) in mammalian sperm and then examine two areas: (i) the regulation of hyperactivation by [Ca2+](i) and the pivotal roles played by CatSpers (sperm-specific, Ca2+-permeable membrane channels) and intracellular Ca2+ stores in this process and (ii) the elevation of [Ca2+](i) and consequent modulation of motility caused by progesterone including the ability of progesterone at micromolar concentrations to cause sperm hyperactivation and/or accumulation and the recent discovery that progesterone, at picomolar concentrations, acts as a chemoattractant for mammalian sperm.
Original language | English |
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Article number | 3105 |
Pages (from-to) | 5623-5637 |
Number of pages | 15 |
Journal | Frontiers in Bioscience-Landmark |
Volume | 13 |
DOIs | |
Publication status | Published - 2008 |
Keywords
- Sperm
- Calcium
- Motility
- Hyperactivation
- Chemotaxis
- Progesterone
- CatSper
- Calcium store
- Ryanodine receptor
- Review
- Inositol 1,4,5-Trisphosphate receptor
- Secretory pathway CA2+ atpase
- Dependent calcium channels
- INDUCED ACROSOME REACTION
- Sea urchin spermatozoa
- Catsper2 null sperm
- Mouse sperm
- Hyperactivated motility
- Intracellular CA2+
- Zona pellucida