Ca2+ signalling in the control of motility and guidance in mammalian sperm

Stephen John Publicover; Laura Cecilia  Giojalas; Maria Eugenia  Teves; Gisela Sofia Mendes Machado de Oliveira; Aduen Andres Morales Garcia; Christopher Lowther Robert Barratt; Claire Victoria Harper

doi:10.2741/3105

Ca2+ signalling in the control of motility and guidance in mammalian sperm

Stephen John Publicover (Lead / Corresponding author)
, Laura Cecilia Giojalas
, Maria Eugenia Teves
, Gisela Sofia Mendes Machado de Oliveira
, Aduen Andres Morales Garcia
, Christopher Lowther Robert Barratt
, Claire Victoria Harper

Research output: Contribution to journal › Article › peer-review

110 Citations (Scopus)

Abstract

Ca2+ signalling in the sperm plays a key role in the regulation of events preceding fertilisation. Control of motility, including hyperactivation and chemotaxis, is particularly dependent upon [Ca2+](i) signalling in the principal piece of the flagellum and the midpiece. Here we briefly review the processes that contribute to regulation of [Ca2+](i) in mammalian sperm and then examine two areas: (i) the regulation of hyperactivation by [Ca2+](i) and the pivotal roles played by CatSpers (sperm-specific, Ca2+-permeable membrane channels) and intracellular Ca2+ stores in this process and (ii) the elevation of [Ca2+](i) and consequent modulation of motility caused by progesterone including the ability of progesterone at micromolar concentrations to cause sperm hyperactivation and/or accumulation and the recent discovery that progesterone, at picomolar concentrations, acts as a chemoattractant for mammalian sperm.

Original language	English
Article number	3105
Pages (from-to)	5623-5637
Number of pages	15
Journal	Frontiers in Bioscience-Landmark
Volume	13
DOIs	https://doi.org/10.2741/3105
Publication status	Published - 2008

Keywords

Sperm
Calcium
Motility
Hyperactivation
Chemotaxis
Progesterone
CatSper
Calcium store
Ryanodine receptor
Review
Inositol 1,4,5-Trisphosphate receptor
Secretory pathway CA2+ atpase
Dependent calcium channels
INDUCED ACROSOME REACTION
Sea urchin spermatozoa
Catsper2 null sperm
Mouse sperm
Hyperactivated motility
Intracellular CA2+
Zona pellucida

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10.2741/3105

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title = "Ca2+ signalling in the control of motility and guidance in mammalian sperm",

abstract = "Ca2+ signalling in the sperm plays a key role in the regulation of events preceding fertilisation. Control of motility, including hyperactivation and chemotaxis, is particularly dependent upon [Ca2+](i) signalling in the principal piece of the flagellum and the midpiece. Here we briefly review the processes that contribute to regulation of [Ca2+](i) in mammalian sperm and then examine two areas: (i) the regulation of hyperactivation by [Ca2+](i) and the pivotal roles played by CatSpers (sperm-specific, Ca2+-permeable membrane channels) and intracellular Ca2+ stores in this process and (ii) the elevation of [Ca2+](i) and consequent modulation of motility caused by progesterone including the ability of progesterone at micromolar concentrations to cause sperm hyperactivation and/or accumulation and the recent discovery that progesterone, at picomolar concentrations, acts as a chemoattractant for mammalian sperm.",

keywords = "Sperm, Calcium, Motility, Hyperactivation, Chemotaxis, Progesterone, CatSper, Calcium store, Ryanodine receptor, Review, Inositol 1,4,5-Trisphosphate receptor, Secretory pathway CA2+ atpase, Dependent calcium channels, INDUCED ACROSOME REACTION, Sea urchin spermatozoa, Catsper2 null sperm, Mouse sperm, Hyperactivated motility, Intracellular CA2+, Zona pellucida",

author = "Publicover, \{Stephen John\} and Giojalas, \{Laura Cecilia\} and Teves, \{Maria Eugenia\} and \{de Oliveira\}, \{Gisela Sofia Mendes Machado\} and Garcia, \{Aduen Andres Morales\} and Barratt, \{Christopher Lowther Robert\} and Harper, \{Claire Victoria\}",

year = "2008",

doi = "10.2741/3105",

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AU - Publicover, Stephen John

AU - Giojalas, Laura Cecilia

AU - Teves, Maria Eugenia

AU - de Oliveira, Gisela Sofia Mendes Machado

AU - Garcia, Aduen Andres Morales

AU - Barratt, Christopher Lowther Robert

AU - Harper, Claire Victoria

PY - 2008

Y1 - 2008

N2 - Ca2+ signalling in the sperm plays a key role in the regulation of events preceding fertilisation. Control of motility, including hyperactivation and chemotaxis, is particularly dependent upon [Ca2+](i) signalling in the principal piece of the flagellum and the midpiece. Here we briefly review the processes that contribute to regulation of [Ca2+](i) in mammalian sperm and then examine two areas: (i) the regulation of hyperactivation by [Ca2+](i) and the pivotal roles played by CatSpers (sperm-specific, Ca2+-permeable membrane channels) and intracellular Ca2+ stores in this process and (ii) the elevation of [Ca2+](i) and consequent modulation of motility caused by progesterone including the ability of progesterone at micromolar concentrations to cause sperm hyperactivation and/or accumulation and the recent discovery that progesterone, at picomolar concentrations, acts as a chemoattractant for mammalian sperm.

AB - Ca2+ signalling in the sperm plays a key role in the regulation of events preceding fertilisation. Control of motility, including hyperactivation and chemotaxis, is particularly dependent upon [Ca2+](i) signalling in the principal piece of the flagellum and the midpiece. Here we briefly review the processes that contribute to regulation of [Ca2+](i) in mammalian sperm and then examine two areas: (i) the regulation of hyperactivation by [Ca2+](i) and the pivotal roles played by CatSpers (sperm-specific, Ca2+-permeable membrane channels) and intracellular Ca2+ stores in this process and (ii) the elevation of [Ca2+](i) and consequent modulation of motility caused by progesterone including the ability of progesterone at micromolar concentrations to cause sperm hyperactivation and/or accumulation and the recent discovery that progesterone, at picomolar concentrations, acts as a chemoattractant for mammalian sperm.

KW - Sperm

KW - Calcium

KW - Motility

KW - Hyperactivation

KW - Chemotaxis

KW - Progesterone

KW - CatSper

KW - Calcium store

KW - Ryanodine receptor

KW - Review

KW - Inositol 1,4,5-Trisphosphate receptor

KW - Secretory pathway CA2+ atpase

KW - Dependent calcium channels

KW - INDUCED ACROSOME REACTION

KW - Sea urchin spermatozoa

KW - Catsper2 null sperm

KW - Mouse sperm

KW - Hyperactivated motility

KW - Intracellular CA2+

KW - Zona pellucida

U2 - 10.2741/3105

DO - 10.2741/3105

M3 - Article

SN - 1093-9946

VL - 13

SP - 5623

EP - 5637

JO - Frontiers in Bioscience-Landmark

JF - Frontiers in Bioscience-Landmark

M1 - 3105

ER -

Ca2+ signalling in the control of motility and guidance in mammalian sperm

Abstract

Keywords

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