Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways

Angela I. M. Barth, Inke S. Näthke, W. James Nelson

    Research output: Contribution to journalArticle

    471 Citations (Scopus)

    Abstract

    Cadherins play important roles in cell-cell adhesion during tissue differentiation. Cadherins are linked to the actin cytoskeleton by catenins (beta-catenin/armadillo, plakoglobin, and alpha-catenin). Recent results show that beta-catenin also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases and phosphatases and Wnt/Wingless. Interplay between these cytoskeletal complexes and signaling pathways may regulate morphogenesis.
    Original languageEnglish
    Pages (from-to)683-690
    Number of pages8
    JournalCurrent Opinion in Cell Biology
    Volume9
    Issue number5
    DOIs
    Publication statusPublished - 1997

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