Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways

Angela I. M. Barth; Inke S. Näthke; W. James Nelson

doi:10.1016/S0955-0674(97)80122-6

Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways

Angela I. M. Barth
, Inke S. Näthke
, W. James Nelson

Research output: Contribution to journal › Article › peer-review

494 Citations (Scopus)

Abstract

Cadherins play important roles in cell-cell adhesion during tissue differentiation. Cadherins are linked to the actin cytoskeleton by catenins (beta-catenin/armadillo, plakoglobin, and alpha-catenin). Recent results show that beta-catenin also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases and phosphatases and Wnt/Wingless. Interplay between these cytoskeletal complexes and signaling pathways may regulate morphogenesis.

Original language	English
Pages (from-to)	683-690
Number of pages	8
Journal	Current Opinion in Cell Biology
Volume	9
Issue number	5
DOIs	https://doi.org/10.1016/S0955-0674(97)80122-6
Publication status	Published - 1997

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abstract = "Cadherins play important roles in cell-cell adhesion during tissue differentiation. Cadherins are linked to the actin cytoskeleton by catenins (beta-catenin/armadillo, plakoglobin, and alpha-catenin). Recent results show that beta-catenin also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases and phosphatases and Wnt/Wingless. Interplay between these cytoskeletal complexes and signaling pathways may regulate morphogenesis.",

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PY - 1997

Y1 - 1997

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AB - Cadherins play important roles in cell-cell adhesion during tissue differentiation. Cadherins are linked to the actin cytoskeleton by catenins (beta-catenin/armadillo, plakoglobin, and alpha-catenin). Recent results show that beta-catenin also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases and phosphatases and Wnt/Wingless. Interplay between these cytoskeletal complexes and signaling pathways may regulate morphogenesis.

U2 - 10.1016/S0955-0674(97)80122-6

DO - 10.1016/S0955-0674(97)80122-6

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EP - 690

JO - Current Opinion in Cell Biology

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Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways

Abstract

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