Caesarean section versus vaginal delivery for preventing mother to infant hepatitis C virus transmission

TY - JOUR

T1 - Caesarean section versus vaginal delivery for preventing mother to infant hepatitis C virus transmission

AU - McIntyre, P. G.

AU - Tosh, Karen

AU - McGuire, William

PY - 2006/10/18

Y1 - 2006/10/18

N2 - BackgroundObservational studies have generally not provided evidence that delivery by caesarean section reduces perinatal hepatitis C virus (HCV) transmission. However, these studies have methodological weaknesses with potential for bias and their findings should be interpreted with caution. ObjectivesTo assess the evidence from randomised controlled trials that a policy of delivery by planned caesarean section versus vaginal delivery reduces mother to infant HCV transmission. Search methodsWe searched the Cochrane Pregnancy and Childbirth Group's Trials Register (March 2010). Selection criteriaControlled trials using random or quasi‐random participant allocation that compared a policy of planned elective caesarean section versus vaginal birth for mothers with HCV infection. Data collection and analysisWe did not identify any randomised controlled trials. Main resultsWe did not identify any randomised controlled trials. Authors' conclusionsCurrently, there is no evidence from randomised controlled trials upon which to base any practice recommendations regarding planned caesarean section versus vaginal delivery for preventing mother to infant hepatitis C virus transmission. In the absence of trial data, evidence to inform women and carers is only available from observational studies that are subject to biases. Systematic review of these studies is needed. There is a need to determine whether women and healthcare providers would support a large pragmatic randomised controlled trial to provide evidence regarding the benefits and harms of planned elective caesarean section versus planned vaginal birth for women with HCV infection.

AB - BackgroundObservational studies have generally not provided evidence that delivery by caesarean section reduces perinatal hepatitis C virus (HCV) transmission. However, these studies have methodological weaknesses with potential for bias and their findings should be interpreted with caution. ObjectivesTo assess the evidence from randomised controlled trials that a policy of delivery by planned caesarean section versus vaginal delivery reduces mother to infant HCV transmission. Search methodsWe searched the Cochrane Pregnancy and Childbirth Group's Trials Register (March 2010). Selection criteriaControlled trials using random or quasi‐random participant allocation that compared a policy of planned elective caesarean section versus vaginal birth for mothers with HCV infection. Data collection and analysisWe did not identify any randomised controlled trials. Main resultsWe did not identify any randomised controlled trials. Authors' conclusionsCurrently, there is no evidence from randomised controlled trials upon which to base any practice recommendations regarding planned caesarean section versus vaginal delivery for preventing mother to infant hepatitis C virus transmission. In the absence of trial data, evidence to inform women and carers is only available from observational studies that are subject to biases. Systematic review of these studies is needed. There is a need to determine whether women and healthcare providers would support a large pragmatic randomised controlled trial to provide evidence regarding the benefits and harms of planned elective caesarean section versus planned vaginal birth for women with HCV infection.

UR - https://pmc.ncbi.nlm.nih.gov/articles/PMC8895451/

UR - https://www.scopus.com/pages/publications/34548145021

U2 - 10.1002/14651858.CD005546.pub2

DO - 10.1002/14651858.CD005546.pub2

M3 - Review article

C2 - 17054264

AN - SCOPUS:34548145021

SN - 1469-493X

JO - Cochrane Database of Systematic Reviews

JF - Cochrane Database of Systematic Reviews

IS - 4

M1 - CD005546

ER -