Projects per year
Acute respiratory distress syndrome (ARDS) caused by SARS-CoV-2 is largely the result of a dysregulated host response, followed by damage to alveolar cells and lung fibrosis. Exacerbated proinflammatory cytokines release (cytokine storm) and loss of T lymphocytes (leukopenia) characterize the most aggressive presentation. We propose that a multifaceted anti-inflammatory strategy based on pharmacological activation of nuclear factor erythroid 2 p45-related factor 2 (NRF2) can be deployed against the virus. The strategy provides robust cytoprotection by restoring redox and protein homeostasis, promoting resolution of inflammation, and facilitating repair. NRF2 activators such as sulforaphane and bardoxolone methyl are already in clinical trials. The safety and efficacy information of these modulators in humans, together with their well-documented cytoprotective and anti-inflammatory effects in preclinical models, highlight the potential of this armamentarium for deployment to the battlefield against COVID-19.
|Number of pages||13|
|Journal||Trends in Pharmacological Sciences|
|Early online date||14 Jul 2020|
|Publication status||Published - Sept 2020|
- anti-inflammatory ARDS
- bardoxolone methyl
ASJC Scopus subject areas
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- 3 Finished
Method Development for Quantitative Assessment of Protein Turnover in Live Cells at Subcellular Resolution
Dinkova-Kostova, A., Muqit, M. & Saurin, A.
1/03/18 → 31/12/19