Cannabinoid Receptor-Related Orphan G Protein-Coupled Receptors

Andrew Irving (Lead / Corresponding author), Ghayth Abdulrazzaq, Sue L. F. Chan, June Penman, Jenni Harvey, Stephen P. H. Alexander

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

    20 Citations (Scopus)

    Abstract

    Of the druggable group of G protein-coupled receptors in the human genome, a number remain which have yet to be paired with an endogenous ligand – orphan GPCR. Amongst these100 or so entities, three have been linked to the cannabinoid system. GPR18, GPR55 and GPR119 exhibit limited sequence homology with the established CB1 and CB2 cannabinoid receptors. However, the pharmacology of these orphan receptors display overlap with CB1 and CB2 receptors, particularly for GPR18 and GPR55. The linking of GPR119 to the cannabinoid receptors is less convincing and emanates from structural similarities of endogenous ligands active at these GPCR, but which do not cross-react. This review describes the evidence for describing these orphan GPCR as cannabinoid receptor-like receptors.
    Original languageEnglish
    Title of host publicationCannabinoid Pharmacology
    EditorsDavid Kendall, Stephen P. H. Alexander
    Place of PublicationCambridge, MA
    PublisherAcademic Press
    Pages223-247
    Number of pages25
    Volume80
    ISBN (Electronic)9780128112335
    ISBN (Print)9780128112328
    DOIs
    Publication statusPublished - Jun 2017

    Publication series

    NameAdvances in Pharmacology
    PublisherAcademic Press
    Volume80
    ISSN (Print)1054-3589

    Keywords

    • GPR18
    • GPR55
    • GPR119
    • N-arachidonoylglycine
    • lysophosphatidylinositol
    • N-oleoylethanolamine

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  • Cite this

    Irving, A., Abdulrazzaq, G., Chan, S. L. F., Penman, J., Harvey, J., & Alexander, S. P. H. (2017). Cannabinoid Receptor-Related Orphan G Protein-Coupled Receptors. In D. Kendall, & S. P. H. Alexander (Eds.), Cannabinoid Pharmacology (Vol. 80, pp. 223-247). (Advances in Pharmacology; Vol. 80). Academic Press. https://doi.org/10.1016/bs.apha.2017.04.004