Cannabinoid Receptor-Related Orphan G Protein-Coupled Receptors

Andrew Irving (Lead / Corresponding author), Ghayth Abdulrazzaq, Sue L. F. Chan, June Penman, Jenni Harvey, Stephen P. H. Alexander

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

    10 Citations (Scopus)

    Abstract

    Of the druggable group of G protein-coupled receptors in the human genome, a number remain which have yet to be paired with an endogenous ligand – orphan GPCR. Amongst these100 or so entities, three have been linked to the cannabinoid system. GPR18, GPR55 and GPR119 exhibit limited sequence homology with the established CB1 and CB2 cannabinoid receptors. However, the pharmacology of these orphan receptors display overlap with CB1 and CB2 receptors, particularly for GPR18 and GPR55. The linking of GPR119 to the cannabinoid receptors is less convincing and emanates from structural similarities of endogenous ligands active at these GPCR, but which do not cross-react. This review describes the evidence for describing these orphan GPCR as cannabinoid receptor-like receptors.
    Original languageEnglish
    Title of host publicationCannabinoid Pharmacology
    EditorsDavid Kendall, Stephen P. H. Alexander
    Place of PublicationCambridge, MA
    PublisherAcademic Press
    Pages223-247
    Number of pages25
    Volume80
    ISBN (Electronic)9780128112335
    ISBN (Print)9780128112328
    DOIs
    Publication statusPublished - Jun 2017

    Publication series

    NameAdvances in Pharmacology
    PublisherAcademic Press
    Volume80
    ISSN (Print)1054-3589

    Fingerprint

    Cannabinoid Receptor CB2
    Cannabinoid Receptor CB1
    Cannabinoid Receptors
    G-Protein-Coupled Receptors
    Ligands
    Cannabinoids
    Human Genome
    Sequence Homology
    Pharmacology

    Keywords

    • GPR18
    • GPR55
    • GPR119
    • N-arachidonoylglycine
    • lysophosphatidylinositol
    • N-oleoylethanolamine

    Cite this

    Irving, A., Abdulrazzaq, G., Chan, S. L. F., Penman, J., Harvey, J., & Alexander, S. P. H. (2017). Cannabinoid Receptor-Related Orphan G Protein-Coupled Receptors. In D. Kendall, & S. P. H. Alexander (Eds.), Cannabinoid Pharmacology (Vol. 80, pp. 223-247). (Advances in Pharmacology; Vol. 80). Cambridge, MA: Academic Press. https://doi.org/10.1016/bs.apha.2017.04.004
    Irving, Andrew ; Abdulrazzaq, Ghayth ; Chan, Sue L. F. ; Penman, June ; Harvey, Jenni ; Alexander, Stephen P. H. / Cannabinoid Receptor-Related Orphan G Protein-Coupled Receptors. Cannabinoid Pharmacology. editor / David Kendall ; Stephen P. H. Alexander. Vol. 80 Cambridge, MA : Academic Press, 2017. pp. 223-247 (Advances in Pharmacology).
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    abstract = "Of the druggable group of G protein-coupled receptors in the human genome, a number remain which have yet to be paired with an endogenous ligand – orphan GPCR. Amongst these100 or so entities, three have been linked to the cannabinoid system. GPR18, GPR55 and GPR119 exhibit limited sequence homology with the established CB1 and CB2 cannabinoid receptors. However, the pharmacology of these orphan receptors display overlap with CB1 and CB2 receptors, particularly for GPR18 and GPR55. The linking of GPR119 to the cannabinoid receptors is less convincing and emanates from structural similarities of endogenous ligands active at these GPCR, but which do not cross-react. This review describes the evidence for describing these orphan GPCR as cannabinoid receptor-like receptors.",
    keywords = "GPR18, GPR55, GPR119, N-arachidonoylglycine, lysophosphatidylinositol, N-oleoylethanolamine",
    author = "Andrew Irving and Ghayth Abdulrazzaq and Chan, {Sue L. F.} and June Penman and Jenni Harvey and Alexander, {Stephen P. H.}",
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    Irving, A, Abdulrazzaq, G, Chan, SLF, Penman, J, Harvey, J & Alexander, SPH 2017, Cannabinoid Receptor-Related Orphan G Protein-Coupled Receptors. in D Kendall & SPH Alexander (eds), Cannabinoid Pharmacology. vol. 80, Advances in Pharmacology, vol. 80, Academic Press, Cambridge, MA, pp. 223-247. https://doi.org/10.1016/bs.apha.2017.04.004

    Cannabinoid Receptor-Related Orphan G Protein-Coupled Receptors. / Irving, Andrew (Lead / Corresponding author); Abdulrazzaq, Ghayth; Chan, Sue L. F.; Penman, June; Harvey, Jenni; Alexander, Stephen P. H.

    Cannabinoid Pharmacology. ed. / David Kendall; Stephen P. H. Alexander. Vol. 80 Cambridge, MA : Academic Press, 2017. p. 223-247 (Advances in Pharmacology; Vol. 80).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

    TY - CHAP

    T1 - Cannabinoid Receptor-Related Orphan G Protein-Coupled Receptors

    AU - Irving, Andrew

    AU - Abdulrazzaq, Ghayth

    AU - Chan, Sue L. F.

    AU - Penman, June

    AU - Harvey, Jenni

    AU - Alexander, Stephen P. H.

    PY - 2017/6

    Y1 - 2017/6

    N2 - Of the druggable group of G protein-coupled receptors in the human genome, a number remain which have yet to be paired with an endogenous ligand – orphan GPCR. Amongst these100 or so entities, three have been linked to the cannabinoid system. GPR18, GPR55 and GPR119 exhibit limited sequence homology with the established CB1 and CB2 cannabinoid receptors. However, the pharmacology of these orphan receptors display overlap with CB1 and CB2 receptors, particularly for GPR18 and GPR55. The linking of GPR119 to the cannabinoid receptors is less convincing and emanates from structural similarities of endogenous ligands active at these GPCR, but which do not cross-react. This review describes the evidence for describing these orphan GPCR as cannabinoid receptor-like receptors.

    AB - Of the druggable group of G protein-coupled receptors in the human genome, a number remain which have yet to be paired with an endogenous ligand – orphan GPCR. Amongst these100 or so entities, three have been linked to the cannabinoid system. GPR18, GPR55 and GPR119 exhibit limited sequence homology with the established CB1 and CB2 cannabinoid receptors. However, the pharmacology of these orphan receptors display overlap with CB1 and CB2 receptors, particularly for GPR18 and GPR55. The linking of GPR119 to the cannabinoid receptors is less convincing and emanates from structural similarities of endogenous ligands active at these GPCR, but which do not cross-react. This review describes the evidence for describing these orphan GPCR as cannabinoid receptor-like receptors.

    KW - GPR18

    KW - GPR55

    KW - GPR119

    KW - N-arachidonoylglycine

    KW - lysophosphatidylinositol

    KW - N-oleoylethanolamine

    U2 - 10.1016/bs.apha.2017.04.004

    DO - 10.1016/bs.apha.2017.04.004

    M3 - Chapter (peer-reviewed)

    SN - 9780128112328

    VL - 80

    T3 - Advances in Pharmacology

    SP - 223

    EP - 247

    BT - Cannabinoid Pharmacology

    A2 - Kendall, David

    A2 - Alexander, Stephen P. H.

    PB - Academic Press

    CY - Cambridge, MA

    ER -

    Irving A, Abdulrazzaq G, Chan SLF, Penman J, Harvey J, Alexander SPH. Cannabinoid Receptor-Related Orphan G Protein-Coupled Receptors. In Kendall D, Alexander SPH, editors, Cannabinoid Pharmacology. Vol. 80. Cambridge, MA: Academic Press. 2017. p. 223-247. (Advances in Pharmacology). https://doi.org/10.1016/bs.apha.2017.04.004