Cap-binding complex (CBC)

Thomas Gonatopoulos-Pournatzis, Victoria H Cowling

    Research output: Contribution to journalReview article

    75 Citations (Scopus)

    Abstract

    The 7mG (7-methylguanosine cap) formed on mRNA is fundamental to eukaryotic gene expression. Protein complexes recruited to 7mG mediate key processing events throughout the lifetime of the transcript. One of the most important mediators of 7mG functions is CBC (cap-binding complex). CBC has a key role in several gene expression mechanisms, including transcription, splicing, transcript export and translation. Gene expression can be regulated by signalling pathways which influence CBC function. The aim of the present review is to discuss the mechanisms by which CBC mediates and co-ordinates multiple gene expression events.
    Original languageEnglish
    Pages (from-to)231-242
    Number of pages12
    JournalBiochemical Journal
    Volume457
    Issue number2
    DOIs
    Publication statusPublished - 15 Jan 2014

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