CAPAM: the mRNA cap adenosine N6 methyltransferase

Victoria Cowling (Lead / Corresponding author)

    Research output: Contribution to journalArticlepeer-review

    17 Citations (Scopus)
    160 Downloads (Pure)

    Abstract

    The mRNA cap is a structure that protects mRNA from degradation and recruits processing and translation factors. A new mRNA capping enzyme has been identified, PCIF1/CAPAM, which methylates adenosine when it is the first transcribed nucleotide. This discovery is crucial for understanding the function of cap adenosine methylation.

    Original languageEnglish
    Article number1545
    Pages (from-to)183-185
    Number of pages3
    JournalTrends in Biochemical Sciences
    Volume44
    Issue number3
    Early online date21 Jan 2019
    DOIs
    Publication statusPublished - 1 Mar 2019

    Keywords

    • CAPAM
    • Pcif1
    • gene expression
    • m6Am
    • mRNA cap
    • mRNA cap methyltransferase

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology

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