CAPAM: the mRNA cap adenosine N6 methyltransferase

Victoria Cowling (Lead / Corresponding author)

Research output: Contribution to journalArticle

Abstract

The mRNA cap is a structure that protects mRNA from degradation and recruits processing and translation factors. A new mRNA capping enzyme has been identified, PCIF1/CAPAM, which methylates adenosine when it is the first transcribed nucleotide. This discovery is crucial for understanding the function of cap adenosine methylation.

Original languageEnglish
Article number1545
Pages (from-to)183-185
Number of pages3
JournalTrends in Biochemical Sciences
Volume44
Issue number3
Early online date21 Jan 2019
DOIs
Publication statusPublished - 1 Mar 2019

Fingerprint

mRNA guanylyltransferase
Methyltransferases
Adenosine
Messenger RNA
Methylation
RNA Stability
Nucleotides
Degradation
Processing

Keywords

  • CAPAM
  • Pcif1
  • gene expression
  • m6Am
  • mRNA cap
  • mRNA cap methyltransferase

Cite this

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CAPAM : the mRNA cap adenosine N6 methyltransferase. / Cowling, Victoria (Lead / Corresponding author).

In: Trends in Biochemical Sciences, Vol. 44, No. 3, 1545, 01.03.2019, p. 183-185.

Research output: Contribution to journalArticle

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