CAPAM: the mRNA cap adenosine N6 methyltransferase

Victoria Cowling (Lead / Corresponding author)

Research output: Contribution to journal › Article

Abstract

The mRNA cap is a structure that protects mRNA from degradation and recruits processing and translation factors. A new mRNA capping enzyme has been identified, PCIF1/CAPAM, which methylates adenosine when it is the first transcribed nucleotide. This discovery is crucial for understanding the function of cap adenosine methylation.

LanguageEnglish
Article number1545
Number of pages3
JournalTrends in Biochemical Sciences
Early online date21 Jan 2019
DOIs
Publication statusE-pub ahead of print - 21 Jan 2019

Fingerprint

mRNA guanylyltransferase
Methyltransferases
Adenosine
Messenger RNA
Methylation
RNA Stability
Nucleotides
Degradation
Processing

Keywords

  • CAPAM
  • Pcif1
  • gene expression
  • m6Am
  • mRNA cap
  • mRNA cap methyltransferase

Cite this

Cowling, Victoria. / CAPAM : the mRNA cap adenosine N6 methyltransferase. In: Trends in Biochemical Sciences. 2019.
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Cowling, V 2019, 'CAPAM: the mRNA cap adenosine N6 methyltransferase', Trends in Biochemical Sciences. https://doi.org/10.1016/j.tibs.2019.01.002

CAPAM : the mRNA cap adenosine N6 methyltransferase. / Cowling, Victoria (Lead / Corresponding author).

In: Trends in Biochemical Sciences, 21.01.2019.

Research output: Contribution to journal › Article

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Cowling V. CAPAM: the mRNA cap adenosine N6 methyltransferase. Trends in Biochemical Sciences. 2019 Jan 21. 1545. https://doi.org/10.1016/j.tibs.2019.01.002

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