Abstract
The mRNA cap is a structure that protects mRNA from degradation and recruits processing and translation factors. A new mRNA capping enzyme has been identified, PCIF1/CAPAM, which methylates adenosine when it is the first transcribed nucleotide. This discovery is crucial for understanding the function of cap adenosine methylation.
| Original language | English |
|---|---|
| Article number | 1545 |
| Pages (from-to) | 183-185 |
| Number of pages | 3 |
| Journal | Trends in Biochemical Sciences |
| Volume | 44 |
| Issue number | 3 |
| Early online date | 21 Jan 2019 |
| DOIs | |
| Publication status | Published - 1 Mar 2019 |
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Keywords
- CAPAM
- Pcif1
- gene expression
- m6Am
- mRNA cap
- mRNA cap methyltransferase
Cite this
}
CAPAM : the mRNA cap adenosine N6 methyltransferase. / Cowling, Victoria (Lead / Corresponding author).
In: Trends in Biochemical Sciences, Vol. 44, No. 3, 1545, 01.03.2019, p. 183-185.Research output: Contribution to journal › Article
TY - JOUR
T1 - CAPAM
T2 - the mRNA cap adenosine N6 methyltransferase
AU - Cowling, Victoria
N1 - VHC is supported by Medical Research Council Senior Fellowship MR/K024213/1, an European Research Council Award 769080 TCAPS and a Royal Society Wolfson Research Merit Award WRM\R1\180008.
PY - 2019/3/1
Y1 - 2019/3/1
N2 - The mRNA cap is a structure that protects mRNA from degradation and recruits processing and translation factors. A new mRNA capping enzyme has been identified, PCIF1/CAPAM, which methylates adenosine when it is the first transcribed nucleotide. This discovery is crucial for understanding the function of cap adenosine methylation.
AB - The mRNA cap is a structure that protects mRNA from degradation and recruits processing and translation factors. A new mRNA capping enzyme has been identified, PCIF1/CAPAM, which methylates adenosine when it is the first transcribed nucleotide. This discovery is crucial for understanding the function of cap adenosine methylation.
KW - CAPAM
KW - Pcif1
KW - gene expression
KW - m6Am
KW - mRNA cap
KW - mRNA cap methyltransferase
UR - http://www.scopus.com/inward/record.url?scp=85060134553&partnerID=8YFLogxK
U2 - 10.1016/j.tibs.2019.01.002
DO - 10.1016/j.tibs.2019.01.002
M3 - Article
C2 - 30679132
VL - 44
SP - 183
EP - 185
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
SN - 0968-0004
IS - 3
M1 - 1545
ER -