CAPAM: the mRNA cap adenosine N6 methyltransferase

Victoria Cowling

doi:10.1016/j.tibs.2019.01.002

CAPAM: the mRNA cap adenosine N6 methyltransferase

Victoria Cowling (Lead / Corresponding author)

Gene Regulation and Expression

Research output: Contribution to journal › Article

5 Citations (Scopus)

105 Downloads (Pure)

Abstract

The mRNA cap is a structure that protects mRNA from degradation and recruits processing and translation factors. A new mRNA capping enzyme has been identified, PCIF1/CAPAM, which methylates adenosine when it is the first transcribed nucleotide. This discovery is crucial for understanding the function of cap adenosine methylation.

Original language	English
Article number	1545
Pages (from-to)	183-185
Number of pages	3
Journal	Trends in Biochemical Sciences
Volume	44
Issue number	3
Early online date	21 Jan 2019
DOIs	https://doi.org/10.1016/j.tibs.2019.01.002
Publication status	Published - 1 Mar 2019

Keywords

CAPAM
Pcif1
gene expression
m6Am
mRNA cap
mRNA cap methyltransferase

Access to Document

10.1016/j.tibs.2019.01.002Licence: CC BY

Final Published VersionFinal published version, 545 KBLicence: CC BY

Link to publication in Scopus

Fingerprint Dive into the research topics of 'CAPAM: the mRNA cap adenosine N6 methyltransferase'. Together they form a unique fingerprint.

Projects

2 Active

mRNA Cap Regulation and Function in CD8 T Cells (TCAPS)

Cowling, V.

COMMISSION OF THE EUROPEAN COMMUNITIES

1/05/18 → 30/04/23

Project: Research

Investigating MRNA Methyl Cap Regulation, Function and Therapeutic Potential (Senior Non-Clinical Fellowship)

Cowling, V.

Medical Research Council

1/01/14 → 31/12/21

Project: Research

Cite this

Cowling, V. (2019). CAPAM: the mRNA cap adenosine N6 methyltransferase. Trends in Biochemical Sciences, 44(3), 183-185. [1545]. https://doi.org/10.1016/j.tibs.2019.01.002

@article{de4a1ee78983496483d0ca2908538e81,

title = "CAPAM: the mRNA cap adenosine N6 methyltransferase",

abstract = "The mRNA cap is a structure that protects mRNA from degradation and recruits processing and translation factors. A new mRNA capping enzyme has been identified, PCIF1/CAPAM, which methylates adenosine when it is the first transcribed nucleotide. This discovery is crucial for understanding the function of cap adenosine methylation.",

keywords = "CAPAM, Pcif1, gene expression, m6Am, mRNA cap, mRNA cap methyltransferase",

author = "Victoria Cowling",

note = "VHC is supported by Medical Research Council Senior Fellowship MR/K024213/1, an European Research Council Award 769080 TCAPS and a Royal Society Wolfson Research Merit Award WRM\R1\180008.",

year = "2019",

month = mar,

day = "1",

doi = "10.1016/j.tibs.2019.01.002",

language = "English",

volume = "44",

pages = "183--185",

journal = "Trends in Biochemical Sciences",

issn = "0968-0004",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - CAPAM

T2 - the mRNA cap adenosine N6 methyltransferase

AU - Cowling, Victoria

N1 - VHC is supported by Medical Research Council Senior Fellowship MR/K024213/1, an European Research Council Award 769080 TCAPS and a Royal Society Wolfson Research Merit Award WRM\R1\180008.

PY - 2019/3/1

Y1 - 2019/3/1

N2 - The mRNA cap is a structure that protects mRNA from degradation and recruits processing and translation factors. A new mRNA capping enzyme has been identified, PCIF1/CAPAM, which methylates adenosine when it is the first transcribed nucleotide. This discovery is crucial for understanding the function of cap adenosine methylation.

AB - The mRNA cap is a structure that protects mRNA from degradation and recruits processing and translation factors. A new mRNA capping enzyme has been identified, PCIF1/CAPAM, which methylates adenosine when it is the first transcribed nucleotide. This discovery is crucial for understanding the function of cap adenosine methylation.

KW - CAPAM

KW - Pcif1

KW - gene expression

KW - m6Am

KW - mRNA cap

KW - mRNA cap methyltransferase

UR - http://www.scopus.com/inward/record.url?scp=85060134553&partnerID=8YFLogxK

U2 - 10.1016/j.tibs.2019.01.002

DO - 10.1016/j.tibs.2019.01.002

M3 - Article

C2 - 30679132

VL - 44

SP - 183

EP - 185

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

SN - 0968-0004

IS - 3

M1 - 1545

ER -