CAPAM: the mRNA cap adenosine N6 methyltransferase

Victoria Cowling (Lead / Corresponding author)

Research output: Contribution to journalArticle

Abstract

The mRNA cap is a structure that protects mRNA from degradation and recruits processing and translation factors. A new mRNA capping enzyme has been identified, PCIF1/CAPAM, which methylates adenosine when it is the first transcribed nucleotide. This discovery is crucial for understanding the function of cap adenosine methylation.

LanguageEnglish
Article number1545
Number of pages3
JournalTrends in Biochemical Sciences
Early online date21 Jan 2019
DOIs
Publication statusE-pub ahead of print - 21 Jan 2019

Fingerprint

mRNA guanylyltransferase
Methyltransferases
Adenosine
Messenger RNA
Methylation
RNA Stability
Nucleotides
Degradation
Processing

Keywords

  • CAPAM
  • Pcif1
  • gene expression
  • m6Am
  • mRNA cap
  • mRNA cap methyltransferase

Cite this

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title = "CAPAM: the mRNA cap adenosine N6 methyltransferase",
abstract = "The mRNA cap is a structure that protects mRNA from degradation and recruits processing and translation factors. A new mRNA capping enzyme has been identified, PCIF1/CAPAM, which methylates adenosine when it is the first transcribed nucleotide. This discovery is crucial for understanding the function of cap adenosine methylation.",
keywords = "CAPAM, Pcif1, gene expression, m6Am, mRNA cap, mRNA cap methyltransferase",
author = "Victoria Cowling",
note = "VHC is supported by Medical Research Council Senior Fellowship MR/K024213/1, an European Research Council Award 769080 TCAPS and a Royal Society Wolfson Research Merit Award WRM\R1\180008.",
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KW - gene expression

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KW - mRNA cap methyltransferase

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