CAPAM: the mRNA cap adenosine N6 methyltransferase

Victoria Cowling

doi:10.1016/j.tibs.2019.01.002

CAPAM: the mRNA cap adenosine N6 methyltransferase

Victoria Cowling (Lead / Corresponding author)

Gene Regulation and Expression

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

127 Downloads (Pure)

Abstract

The mRNA cap is a structure that protects mRNA from degradation and recruits processing and translation factors. A new mRNA capping enzyme has been identified, PCIF1/CAPAM, which methylates adenosine when it is the first transcribed nucleotide. This discovery is crucial for understanding the function of cap adenosine methylation.

Original language	English
Article number	1545
Pages (from-to)	183-185
Number of pages	3
Journal	Trends in Biochemical Sciences
Volume	44
Issue number	3
Early online date	21 Jan 2019
DOIs	https://doi.org/10.1016/j.tibs.2019.01.002
Publication status	Published - 1 Mar 2019

Keywords

CAPAM
Pcif1
gene expression
m6Am
mRNA cap
mRNA cap methyltransferase

Access to Document

10.1016/j.tibs.2019.01.002Licence: CC BY

Final Published VersionFinal published version, 545 KBLicence: CC BY

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2 Active

mRNA Cap Regulation and Function in CD8 T Cells (TCAPS)
Cowling, V.
COMMISSION OF THE EUROPEAN COMMUNITIES
1/05/18 → 31/10/23
Project: Research
Investigating MRNA Methyl Cap Regulation, Function and Therapeutic Potential (Senior Non-Clinical Fellowship)
Cowling, V.
Medical Research Council
1/01/14 → 31/12/21
Project: Research

Cite this

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title = "CAPAM: the mRNA cap adenosine N6 methyltransferase",

abstract = "The mRNA cap is a structure that protects mRNA from degradation and recruits processing and translation factors. A new mRNA capping enzyme has been identified, PCIF1/CAPAM, which methylates adenosine when it is the first transcribed nucleotide. This discovery is crucial for understanding the function of cap adenosine methylation.",

keywords = "CAPAM, Pcif1, gene expression, m6Am, mRNA cap, mRNA cap methyltransferase",

author = "Victoria Cowling",

note = "VHC is supported by Medical Research Council Senior Fellowship MR/K024213/1, an European Research Council Award 769080 TCAPS and a Royal Society Wolfson Research Merit Award WRM\R1\180008.",

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CAPAM: the mRNA cap adenosine N6 methyltransferase

Abstract

Keywords

Access to Document

mRNA Cap Regulation and Function in CD8 T Cells (TCAPS)

Investigating MRNA Methyl Cap Regulation, Function and Therapeutic Potential (Senior Non-Clinical Fellowship)

Cite this