CAPAM: the mRNA cap adenosine N6 methyltransferase

Victoria Cowling (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)
111 Downloads (Pure)


The mRNA cap is a structure that protects mRNA from degradation and recruits processing and translation factors. A new mRNA capping enzyme has been identified, PCIF1/CAPAM, which methylates adenosine when it is the first transcribed nucleotide. This discovery is crucial for understanding the function of cap adenosine methylation.

Original languageEnglish
Article number1545
Pages (from-to)183-185
Number of pages3
JournalTrends in Biochemical Sciences
Issue number3
Early online date21 Jan 2019
Publication statusPublished - 1 Mar 2019


  • Pcif1
  • gene expression
  • m6Am
  • mRNA cap
  • mRNA cap methyltransferase


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