CAPAM: the mRNA cap adenosine N6 methyltransferase

TY - JOUR

T1 - CAPAM

T2 - the mRNA cap adenosine N6 methyltransferase

AU - Cowling, Victoria

N1 - VHC is supported by Medical Research Council Senior Fellowship MR/K024213/1, an European Research Council Award 769080 TCAPS and a Royal Society Wolfson Research Merit Award WRM\R1\180008.

PY - 2019/3/1

Y1 - 2019/3/1

N2 - The mRNA cap is a structure that protects mRNA from degradation and recruits processing and translation factors. A new mRNA capping enzyme has been identified, PCIF1/CAPAM, which methylates adenosine when it is the first transcribed nucleotide. This discovery is crucial for understanding the function of cap adenosine methylation.

AB - The mRNA cap is a structure that protects mRNA from degradation and recruits processing and translation factors. A new mRNA capping enzyme has been identified, PCIF1/CAPAM, which methylates adenosine when it is the first transcribed nucleotide. This discovery is crucial for understanding the function of cap adenosine methylation.

KW - CAPAM

KW - Pcif1

KW - gene expression

KW - m6Am

KW - mRNA cap

KW - mRNA cap methyltransferase

UR - https://www.scopus.com/pages/publications/85060134553

U2 - 10.1016/j.tibs.2019.01.002

DO - 10.1016/j.tibs.2019.01.002

M3 - Article

C2 - 30679132

SN - 0968-0004

VL - 44

SP - 183

EP - 185

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

IS - 3

M1 - 1545

ER -