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Abstract
Diseases which are prevalent in the gastrointestinal (GI) tract, such as Crohn's disease, are a topic of increasing concern because diagnosis and specific treatment are difficult and may be ineffective. New techniques are therefore sought after and this paper describes a proof-of-concept tethered capsule for targeted drug delivery (TDD) in the GI tract. The capsule consists of a camera, illumination, a drug delivery channel and an ultrasound (US) transducer. The transducer is described in detail, including a comparison of different piezoceramic materials that has been carried out. It was found that PZ54 (Ferroperm Piezoceramics, Kvistgaard, Denmark) was the most suitable material for our application. When driven at 4 Vpp, the outer diameter 5 mm PZ54 transducer operates at a frequency f = 4.05 MHz providing an acoustic pressure, Pac = 125 kPa, with a beam diameter, BD = 0.75 mm at the focus. Pressures in the range 50 - 300 kPa have been previously reported as suitable for sonoporation, a process vital in many TDD applications, so this is a promising result. Basic functional testing of the capsule was performed by supplying glass microbubbles (MBs) through the drug delivery channel into the US focus, monitored via the onboard camera. It was found that the acoustic radiation forces have a clear influence on the MBs, significantly changing their direction at the US focus. This suggests that drugs may be targeted to specific tissue in the GI tract by the new capsule. The results translate into a capsule configuration with the potential to be clinically and biologically useful.
Original language | English |
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Title of host publication | 2015 IEEE International Ultrasonics Symposium, IUS 2015 |
Publisher | Institute of Electrical and Electronics Engineers |
ISBN (Print) | 9781479981823 |
DOIs | |
Publication status | Published - 13 Nov 2015 |
Event | IEEE International Ultrasonics Symposium, IUS 2015 - Taipei, Taiwan, Province of China Duration: 21 Oct 2015 → 24 Oct 2015 |
Conference
Conference | IEEE International Ultrasonics Symposium, IUS 2015 |
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Country/Territory | Taiwan, Province of China |
City | Taipei |
Period | 21/10/15 → 24/10/15 |
Keywords
- Capsule Endoscopy
- GI Drug Delivery
- Targeted Drug Delivery
- Therapeutic Capsule
- Ultrasound Capsule
- UmTDD
ASJC Scopus subject areas
- Acoustics and Ultrasonics
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Dive into the research topics of 'Capsule-based ultrasound-mediated targeted gastrointestinal drug delivery'. Together they form a unique fingerprint.Projects
- 1 Finished
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Sonopill: Minimally Invasive Gastrointestinal Diagnosis and Therapy (Joint with University of Glasgow & Heriot Watt University)
Cochran, S. (Investigator), Corner, G. (Investigator), Cuschieri, A. (Investigator), Nathke, I. (Investigator) & Steele, B. (Investigator)
Engineering and Physical Sciences Research Council
27/05/13 → 14/12/18
Project: Research