Capsulotomy for obsessive-compulsive disorder: long-term follow-up of 25 patients

C. Rück, A. Karlsson, H. Nyman, M. Åsberg, P. Svanborg, B.A. Meyerson, Kaj Ericson, J.D. Steele, G. Edman

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    170 Citations (Scopus)


    Context: Capsulotomy is sometimes used as a treatment of last resort in severe and treatment-refractory cases of obsessive-compulsive disorder (OCD). Objective: To evaluate the long-term efficacy and safety of capsulotomy in OCD. Design: Noncontrolled, long-term follow-up trial (mean of 10.9 years after surgery). Setting: University hospital referral center. Patients: Twenty-five consecutive patients with OCD who underwent capsulotomy from 1988 to 2000. Intervention: Unilateral or bilateral capsulotomy. Lesions were created by means of radiofrequency heating (thermocapsulotomy) or gamma radiation (radiosurgery, gammacapsulotomy). Main Outcome Measure: Yale-Brown Obsessive-Compulsive Rating Scale (Y-BOCS) score. Results: The mean Y-BOCS score was 34 preoperatively and 18 at long-term follow-up (P <.001). Response (defined as =35% reduction at long-term follow-up compared with baseline) was seen in 12 patients at long-term follow-up. Nine patients were in remission (Y-BOCS score,
    Original languageEnglish
    Pages (from-to)914-922
    Number of pages9
    JournalArchives of General Psychiatry
    Issue number8
    Publication statusPublished - 2008


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