TY - JOUR
T1 - Capsulotomy for obsessive-compulsive disorder
T2 - long-term follow-up of 25 patients
AU - Rück, C.
AU - Karlsson, A.
AU - Nyman, H.
AU - Åsberg, M.
AU - Svanborg, P.
AU - Meyerson, B.A.
AU - Ericson, Kaj
AU - Steele, J.D.
AU - Edman, G.
N1 - MEDLINE® is the source for the MeSH terms of this document.
PY - 2008
Y1 - 2008
N2 - Context: Capsulotomy is sometimes used as a treatment of last resort in severe and treatment-refractory cases of obsessive-compulsive disorder (OCD). Objective: To evaluate the long-term efficacy and safety of capsulotomy in OCD. Design: Noncontrolled, long-term follow-up trial (mean of 10.9 years after surgery). Setting: University hospital referral center. Patients: Twenty-five consecutive patients with OCD who underwent capsulotomy from 1988 to 2000. Intervention: Unilateral or bilateral capsulotomy. Lesions were created by means of radiofrequency heating (thermocapsulotomy) or gamma radiation (radiosurgery, gammacapsulotomy). Main Outcome Measure: Yale-Brown Obsessive-Compulsive Rating Scale (Y-BOCS) score. Results: The mean Y-BOCS score was 34 preoperatively and 18 at long-term follow-up (P <.001). Response (defined as =35% reduction at long-term follow-up compared with baseline) was seen in 12 patients at long-term follow-up. Nine patients were in remission (Y-BOCS score,
AB - Context: Capsulotomy is sometimes used as a treatment of last resort in severe and treatment-refractory cases of obsessive-compulsive disorder (OCD). Objective: To evaluate the long-term efficacy and safety of capsulotomy in OCD. Design: Noncontrolled, long-term follow-up trial (mean of 10.9 years after surgery). Setting: University hospital referral center. Patients: Twenty-five consecutive patients with OCD who underwent capsulotomy from 1988 to 2000. Intervention: Unilateral or bilateral capsulotomy. Lesions were created by means of radiofrequency heating (thermocapsulotomy) or gamma radiation (radiosurgery, gammacapsulotomy). Main Outcome Measure: Yale-Brown Obsessive-Compulsive Rating Scale (Y-BOCS) score. Results: The mean Y-BOCS score was 34 preoperatively and 18 at long-term follow-up (P <.001). Response (defined as =35% reduction at long-term follow-up compared with baseline) was seen in 12 patients at long-term follow-up. Nine patients were in remission (Y-BOCS score,
UR - http://www.scopus.com/inward/record.url?scp=48949088454&partnerID=8YFLogxK
U2 - 10.1001/archpsyc.65.8.914
DO - 10.1001/archpsyc.65.8.914
M3 - Article
C2 - 18678796
AN - SCOPUS:48949088454
SN - 0003-990X
VL - 65
SP - 914
EP - 922
JO - Archives of General Psychiatry
JF - Archives of General Psychiatry
IS - 8
ER -