Capsulotomy for obsessive-compulsive disorder: long-term follow-up of 25 patients

TY - JOUR

T1 - Capsulotomy for obsessive-compulsive disorder

T2 - long-term follow-up of 25 patients

AU - Rück, C.

AU - Karlsson, A.

AU - Nyman, H.

AU - Åsberg, M.

AU - Svanborg, P.

AU - Meyerson, B.A.

AU - Ericson, Kaj

AU - Steele, J.D.

AU - Edman, G.

N1 - MEDLINE® is the source for the MeSH terms of this document.

PY - 2008

Y1 - 2008

N2 - Context: Capsulotomy is sometimes used as a treatment of last resort in severe and treatment-refractory cases of obsessive-compulsive disorder (OCD). Objective: To evaluate the long-term efficacy and safety of capsulotomy in OCD. Design: Noncontrolled, long-term follow-up trial (mean of 10.9 years after surgery). Setting: University hospital referral center. Patients: Twenty-five consecutive patients with OCD who underwent capsulotomy from 1988 to 2000. Intervention: Unilateral or bilateral capsulotomy. Lesions were created by means of radiofrequency heating (thermocapsulotomy) or gamma radiation (radiosurgery, gammacapsulotomy). Main Outcome Measure: Yale-Brown Obsessive-Compulsive Rating Scale (Y-BOCS) score. Results: The mean Y-BOCS score was 34 preoperatively and 18 at long-term follow-up (P <.001). Response (defined as =35% reduction at long-term follow-up compared with baseline) was seen in 12 patients at long-term follow-up. Nine patients were in remission (Y-BOCS score,

AB - Context: Capsulotomy is sometimes used as a treatment of last resort in severe and treatment-refractory cases of obsessive-compulsive disorder (OCD). Objective: To evaluate the long-term efficacy and safety of capsulotomy in OCD. Design: Noncontrolled, long-term follow-up trial (mean of 10.9 years after surgery). Setting: University hospital referral center. Patients: Twenty-five consecutive patients with OCD who underwent capsulotomy from 1988 to 2000. Intervention: Unilateral or bilateral capsulotomy. Lesions were created by means of radiofrequency heating (thermocapsulotomy) or gamma radiation (radiosurgery, gammacapsulotomy). Main Outcome Measure: Yale-Brown Obsessive-Compulsive Rating Scale (Y-BOCS) score. Results: The mean Y-BOCS score was 34 preoperatively and 18 at long-term follow-up (P <.001). Response (defined as =35% reduction at long-term follow-up compared with baseline) was seen in 12 patients at long-term follow-up. Nine patients were in remission (Y-BOCS score,

UR - https://www.scopus.com/pages/publications/48949088454

U2 - 10.1001/archpsyc.65.8.914

DO - 10.1001/archpsyc.65.8.914

M3 - Article

C2 - 18678796

AN - SCOPUS:48949088454

SN - 0003-990X

VL - 65

SP - 914

EP - 922

JO - Archives of General Psychiatry

JF - Archives of General Psychiatry

IS - 8

ER -