Cardiotoxicity and Chemotherapy: The Role of Precision Medicine

Thyla  Viswanathan; Chim C. Lang; Russell D. Petty; Mark A. Baxter

doi:10.3390/diseases9040090

Cardiotoxicity and Chemotherapy: The Role of Precision Medicine

Thyla Viswanathan, Chim C. Lang, Russell D. Petty, Mark A. Baxter (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

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Abstract

Cancer and cardiovascular disease are the leading causes of death in the United Kingdom. Many systemic anticancer treatments are associated with short- and long-term cardiotoxicity. With improving cancer survival and an ageing population, identifying those patients at the greatest risk of cardiotoxicity from their cancer treatment is becoming a research priority and has led to a new subspecialty: cardio-oncology. In this concise review article, we discuss cardiotoxicity and systemic anticancer therapy, with a focus on chemotherapy. We also discuss the challenge of identifying those at risk and the role of precision medicine as we strive for a personalised approach to this clinical scenario.

Original language	English
Article number	90
Pages (from-to)	1-12
Number of pages	12
Journal	Diseases
Volume	9
Issue number	4
DOIs	https://doi.org/10.3390/diseases9040090
Publication status	Published - 8 Dec 2021

Keywords

cardiotoxicity
cardio-oncology
heart failure
cancer therapy
precision medicine
pharmacogenetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/diseases9040090Licence: CC BY

Final published versionFinal published version, 800 KBLicence: CC BY

Identifying and Validating Predictive Biomarkers in Advanced Oesophagael Adenocarcinoma - A Springboard to REAListic Medicine (BE-REAL)
Baxter, M. (Investigator)
1/10/20 → 29/02/24
Project: Research
PRecision Medicine for Diabetis Individuals: a Joint Malaysia-UK Effort (PRIME) - (Joint with UMBI)
Doney, A. (Investigator), Lang, C. (Investigator), Mordi, I. (Investigator), Palmer, C. (Investigator), Pearson, E. (Investigator) & Trucco, M. (Investigator)
Medical Research Council
31/12/19 → 1/04/23
Project: Research

Cite this

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title = "Cardiotoxicity and Chemotherapy: The Role of Precision Medicine",

abstract = "Cancer and cardiovascular disease are the leading causes of death in the United Kingdom. Many systemic anticancer treatments are associated with short- and long-term cardiotoxicity. With improving cancer survival and an ageing population, identifying those patients at the greatest risk of cardiotoxicity from their cancer treatment is becoming a research priority and has led to a new subspecialty: cardio-oncology. In this concise review article, we discuss cardiotoxicity and systemic anticancer therapy, with a focus on chemotherapy. We also discuss the challenge of identifying those at risk and the role of precision medicine as we strive for a personalised approach to this clinical scenario.",

keywords = "cardiotoxicity, cardio-oncology, heart failure, cancer therapy, precision medicine, pharmacogenetics",

author = "Thyla Viswanathan and Lang, {Chim C.} and Petty, {Russell D.} and Baxter, {Mark A.}",

note = "Funding: M.A.B. is a Clinical Academic Fellow funded by the Scottish Chief Scientist Office. C.C.L. is a Distinguished Professor at the UKM Medical Molecular Biology Institute (UMBI)",

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doi = "10.3390/diseases9040090",

language = "English",

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TY - JOUR

T1 - Cardiotoxicity and Chemotherapy

T2 - The Role of Precision Medicine

AU - Viswanathan, Thyla

AU - Lang, Chim C.

AU - Petty, Russell D.

AU - Baxter, Mark A.

N1 - Funding: M.A.B. is a Clinical Academic Fellow funded by the Scottish Chief Scientist Office. C.C.L. is a Distinguished Professor at the UKM Medical Molecular Biology Institute (UMBI)

PY - 2021/12/8

Y1 - 2021/12/8

N2 - Cancer and cardiovascular disease are the leading causes of death in the United Kingdom. Many systemic anticancer treatments are associated with short- and long-term cardiotoxicity. With improving cancer survival and an ageing population, identifying those patients at the greatest risk of cardiotoxicity from their cancer treatment is becoming a research priority and has led to a new subspecialty: cardio-oncology. In this concise review article, we discuss cardiotoxicity and systemic anticancer therapy, with a focus on chemotherapy. We also discuss the challenge of identifying those at risk and the role of precision medicine as we strive for a personalised approach to this clinical scenario.

AB - Cancer and cardiovascular disease are the leading causes of death in the United Kingdom. Many systemic anticancer treatments are associated with short- and long-term cardiotoxicity. With improving cancer survival and an ageing population, identifying those patients at the greatest risk of cardiotoxicity from their cancer treatment is becoming a research priority and has led to a new subspecialty: cardio-oncology. In this concise review article, we discuss cardiotoxicity and systemic anticancer therapy, with a focus on chemotherapy. We also discuss the challenge of identifying those at risk and the role of precision medicine as we strive for a personalised approach to this clinical scenario.

KW - cardiotoxicity

KW - cardio-oncology

KW - heart failure

KW - cancer therapy

KW - precision medicine

KW - pharmacogenetics

U2 - 10.3390/diseases9040090

DO - 10.3390/diseases9040090

M3 - Article

C2 - 34940028

SN - 2079-9721

VL - 9

SP - 1

EP - 12

JO - Diseases

JF - Diseases

IS - 4

M1 - 90

ER -

Cardiotoxicity and Chemotherapy: The Role of Precision Medicine

Abstract

Keywords

UN SDGs

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Projects

Identifying and Validating Predictive Biomarkers in Advanced Oesophagael Adenocarcinoma - A Springboard to REAListic Medicine (BE-REAL)

PRecision Medicine for Diabetis Individuals: a Joint Malaysia-UK Effort (PRIME) - (Joint with UMBI)

Cite this