Careful screening to target interventions to prevent sudden cardiac death

    Research output: Contribution to journalArticle

    Abstract

    1. Cardiac death is due not only to coronary artery disease, but also to left ventricular (LV) abnormalities (fibrosis, dysfunction) and arrhythmogenic triggers, such as autonomic imbalance. 2. Nitric oxide deficiency could be a key mediator leading not only to coronary atherosclerosis, but also to LV abnormalities and autonomic imbalance. 3. It may be possible to screen for the above abnormalities (e.g. echocardiography and brain natriuretic peptide levels for LV abnormalities, 24 h tapes for autonomic imbalance and QT interval analysis). 4. Once individuals are identified as being at high risk, a range of interventions is possible (e.g. intensive statin therapy or angiotensin-converting enzyme inhibitors if LV abnormalities or autonomic imbalance are found).
    Original languageEnglish
    Pages (from-to)219-222
    Number of pages4
    JournalClinical and Experimental Pharmacology & Physiology
    Volume28
    Issue number3
    DOIs
    Publication statusPublished - 2001
    Event33rd Annual Scientific Meeting of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists - Sydney, Australia
    Duration: 4 Dec 19998 Dec 1999

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