TY - JOUR
T1 - Caspase-1
T2 - The inflammasome and beyond
AU - Sollberger, Gabriel
AU - Strittmatter, Gerhard E.
AU - Garstkiewicz, Martha
AU - Sand, Jennifer
AU - Beer, Hans Dietmar
PY - 2014/2/1
Y1 - 2014/2/1
N2 - Caspase-1 plays a fundamental role in innate immunity and in several important inflammatory diseases as the protease activates the pro-inflammatory cytokines proIL-1β and proIL-18. Caspase-1 itself is activated in different inflammasome complexes, which assemble in response to a variety of exogenous and endogenous stressors. More recently, pyroptosis, a caspase-1-dependent type of programmed cell death, has been identified that is able to support secreted IL-1 and IL-18 in triggering an inflammatory response. Whereas these 'canonical' activities are well appreciated, this review also highlights less-known pathways and molecules activated by caspase-1. There is evidence that caspase-1 supports cell survival by activation of NF-κB, induction of membrane repair and regulation of unconventional secretion of certain proteins. The physiologic effects of processing of other downstream targets, such as proteins involved in glycolysis or activation of caspase-7, are less well understood. However, there is increasing evidence that caspase-1 contributes to innate and adaptive immunologic defense mechanisms, repair and pathologic conditions by the regulation of several different and partially opposing pathways.
AB - Caspase-1 plays a fundamental role in innate immunity and in several important inflammatory diseases as the protease activates the pro-inflammatory cytokines proIL-1β and proIL-18. Caspase-1 itself is activated in different inflammasome complexes, which assemble in response to a variety of exogenous and endogenous stressors. More recently, pyroptosis, a caspase-1-dependent type of programmed cell death, has been identified that is able to support secreted IL-1 and IL-18 in triggering an inflammatory response. Whereas these 'canonical' activities are well appreciated, this review also highlights less-known pathways and molecules activated by caspase-1. There is evidence that caspase-1 supports cell survival by activation of NF-κB, induction of membrane repair and regulation of unconventional secretion of certain proteins. The physiologic effects of processing of other downstream targets, such as proteins involved in glycolysis or activation of caspase-7, are less well understood. However, there is increasing evidence that caspase-1 contributes to innate and adaptive immunologic defense mechanisms, repair and pathologic conditions by the regulation of several different and partially opposing pathways.
KW - Caspases
KW - IL-1
KW - inflammasome
KW - inflammation
KW - unconventional protein secretion
UR - http://www.scopus.com/inward/record.url?scp=84892746507&partnerID=8YFLogxK
U2 - 10.1177/1753425913484374
DO - 10.1177/1753425913484374
M3 - Review article
C2 - 23676582
AN - SCOPUS:84892746507
VL - 20
SP - 115
EP - 125
JO - Innate Immunity
JF - Innate Immunity
SN - 1753-4259
IS - 2
ER -