Catalysis by the nucleolytic ribozymes

David M. J. Lilley

doi:10.1042/BST0390641

Catalysis by the nucleolytic ribozymes

David M. J. Lilley

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

The nucleolytic ribozymes use general acid-base catalysis to contribute significantly to their rate enhancement. The VS (Varkud satellite) ribozyme uses a guanine and an adenine nucleobase as general base and acid respectively in the cleavage reaction. The hairpin ribozyme is probably closely similar, while the remaining nucleolytic ribozymes provide some interesting contrasts.

Original language	English
Pages (from-to)	641-646
Number of pages	6
Journal	Biochemical Society Transactions
Volume	39
DOIs	https://doi.org/10.1042/BST0390641
Publication status	Published - Apr 2011

Keywords

catalytic mechanism
general acid-base catalysis
hairpin ribozyme
ribozyme
RNA catalysis
Varkud satellite ribozyme (VS ribozyme)
DELTA VIRUS RIBOZYME
VARKUD SATELLITE RIBOZYME
ACTIVE-SITE GUANINE
ACID-BASE CATALYSIS
HAIRPIN RIBOZYME
HAMMERHEAD RIBOZYME
CRYSTAL-STRUCTURE
METAL-BINDING
RNA
NEUROSPORA

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title = "Catalysis by the nucleolytic ribozymes",

abstract = "The nucleolytic ribozymes use general acid-base catalysis to contribute significantly to their rate enhancement. The VS (Varkud satellite) ribozyme uses a guanine and an adenine nucleobase as general base and acid respectively in the cleavage reaction. The hairpin ribozyme is probably closely similar, while the remaining nucleolytic ribozymes provide some interesting contrasts.",

keywords = "catalytic mechanism, general acid-base catalysis, hairpin ribozyme, ribozyme, RNA catalysis, Varkud satellite ribozyme (VS ribozyme), DELTA VIRUS RIBOZYME, VARKUD SATELLITE RIBOZYME, ACTIVE-SITE GUANINE, ACID-BASE CATALYSIS, HAIRPIN RIBOZYME, HAMMERHEAD RIBOZYME, CRYSTAL-STRUCTURE, METAL-BINDING, RNA, NEUROSPORA",

author = "Lilley, {David M. J.}",

year = "2011",

month = apr,

doi = "10.1042/BST0390641",

language = "English",

volume = "39",

pages = "641--646",

journal = "Biochemical Society Transactions",

issn = "0300-5127",

publisher = "Portland Press",

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TY - JOUR

T1 - Catalysis by the nucleolytic ribozymes

AU - Lilley, David M. J.

PY - 2011/4

Y1 - 2011/4

N2 - The nucleolytic ribozymes use general acid-base catalysis to contribute significantly to their rate enhancement. The VS (Varkud satellite) ribozyme uses a guanine and an adenine nucleobase as general base and acid respectively in the cleavage reaction. The hairpin ribozyme is probably closely similar, while the remaining nucleolytic ribozymes provide some interesting contrasts.

AB - The nucleolytic ribozymes use general acid-base catalysis to contribute significantly to their rate enhancement. The VS (Varkud satellite) ribozyme uses a guanine and an adenine nucleobase as general base and acid respectively in the cleavage reaction. The hairpin ribozyme is probably closely similar, while the remaining nucleolytic ribozymes provide some interesting contrasts.

KW - catalytic mechanism

KW - general acid-base catalysis

KW - hairpin ribozyme

KW - ribozyme

KW - RNA catalysis

KW - Varkud satellite ribozyme (VS ribozyme)

KW - DELTA VIRUS RIBOZYME

KW - VARKUD SATELLITE RIBOZYME

KW - ACTIVE-SITE GUANINE

KW - ACID-BASE CATALYSIS

KW - HAIRPIN RIBOZYME

KW - HAMMERHEAD RIBOZYME

KW - CRYSTAL-STRUCTURE

KW - METAL-BINDING

KW - RNA

KW - NEUROSPORA

U2 - 10.1042/BST0390641

DO - 10.1042/BST0390641

M3 - Article

SN - 0300-5127

VL - 39

SP - 641

EP - 646

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

ER -

Catalysis by the nucleolytic ribozymes

Abstract

Keywords

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