Catalysis by the nucleolytic ribozymes

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    Abstract

    The nucleolytic ribozymes use general acid-base catalysis to contribute significantly to their rate enhancement. The VS (Varkud satellite) ribozyme uses a guanine and an adenine nucleobase as general base and acid respectively in the cleavage reaction. The hairpin ribozyme is probably closely similar, while the remaining nucleolytic ribozymes provide some interesting contrasts.

    Original languageEnglish
    Pages (from-to)641-646
    Number of pages6
    JournalBiochemical Society Transactions
    Volume39
    DOIs
    Publication statusPublished - Apr 2011

    Keywords

    • catalytic mechanism
    • general acid-base catalysis
    • hairpin ribozyme
    • ribozyme
    • RNA catalysis
    • Varkud satellite ribozyme (VS ribozyme)
    • DELTA VIRUS RIBOZYME
    • VARKUD SATELLITE RIBOZYME
    • ACTIVE-SITE GUANINE
    • ACID-BASE CATALYSIS
    • HAIRPIN RIBOZYME
    • HAMMERHEAD RIBOZYME
    • CRYSTAL-STRUCTURE
    • METAL-BINDING
    • RNA
    • NEUROSPORA

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