Catalytic Friedel-Crafts Alkylation of Electron Rich Aromatic Derivatives with α-Aryl Diazoacetates Mediated by Brønsted Acids

TY - JOUR

T1 - Catalytic Friedel-Crafts Alkylation of Electron Rich Aromatic Derivatives with α-Aryl Diazoacetates Mediated by Brønsted Acids

AU - Gallo, Rafael D. C.

AU - Momo, Patrícia B.

AU - Day, David P.

AU - Burtoloso, Antonio C. B.

N1 - Funding Information: The authors thank FAPESP (Research Supporting Foundation of the State of Sao Paulo) for financial support (2017/23329-9), a fellowship to P.B.M. (2015/22003-7), and a fellowship to D.P.D. (2019/05002-8). The authors also thank CNPq for a research fellowship to A.C.B.B. (303437/2015-4) and a fellowship to R.D.C.G. The authors also thank IQSC-USP for facilities and FAPESP (2013/50228-8 and 2009/54040-8) for HRMS multiuser equipment. Publisher Copyright: Copyright © 2020 American Chemical Society.

PY - 2020/3/20

Y1 - 2020/3/20

N2 - The catalytic protonation of aryl diazoacetates by strong Brønsted acids, followed by a Friedel-Crafts alkylation reaction with electron rich aromatic compounds, is reported. The reaction provided in a direct fashion 24 geminal diarylacetates in yields of ≤92%.

AB - The catalytic protonation of aryl diazoacetates by strong Brønsted acids, followed by a Friedel-Crafts alkylation reaction with electron rich aromatic compounds, is reported. The reaction provided in a direct fashion 24 geminal diarylacetates in yields of ≤92%.

UR - https://www.scopus.com/pages/publications/85081654693

U2 - 10.1021/acs.orglett.0c00540

DO - 10.1021/acs.orglett.0c00540

M3 - Article

C2 - 32133862

AN - SCOPUS:85081654693

SN - 1944-8244

VL - 22

SP - 2239

EP - 2343

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 6

ER -