Catalytic RNA and the origin of genetic systems

Angus I. Lamond, Toby J. Gibson

Research output: Contribution to journalArticle

22 Citations (Scopus)


The recent discovery of catalytic RNA molecules has provoked enormous interest in the origin of life and has given rise to new speculations about how living systems developed on the primitive earth. Here we outline why the discovery of catalytic RNA molecules has profound evolutionary implications, and then go on to discuss models for the emergence of metabolic complexity and protein synthesis in a primitive 'RNA world', emphasizing the constraints imposed on such models by genetical arguments.

Original languageEnglish
Pages (from-to)145-149
Number of pages5
JournalTrends in Genetics
Issue numberC
Publication statusPublished - 1990


Cite this