Abstract
The present study compares the mitogen-activated protein (MAP) kinase responses in T cells activated with the CD28 ligands B7-1 (CD80) and B7-2/B70 (CD86). Ligands B7-1 and B7-2 do not activate the Raf-1/ERK2 cascade, but share the ability to activate related Jun kinases. These natural ligands for CD28 had no stimulatory effect alone on Jun kinase activation, but the data show that B7-1 and B7-2 could both co-operate with intracellular Ca2+ increase and protein kinase C (PKC) activation to stimulate Jun kinases. The present study shows that the interaction of CD28 with its ligands B7-1 and B7-2 can induce identical signal transduction through the MAP kinase cascades.
Original language | English |
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Pages (from-to) | 63-70 |
Number of pages | 8 |
Journal | Molecular Immunology |
Volume | 33 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 1996 |
Keywords
- B7-1
- B7-2
- Jun kinases
- Signal transduction
ASJC Scopus subject areas
- Immunology
- Molecular Biology