CD28 signal transduction pathways. A comparison of B7-1 and B7-2 regulation of the MAP kinases: ERK2 and Jun kinases

Jacques A. Nunès (Lead / Corresponding author), Michaela Battifora, James R. Woodgett, Alemseged Truneh, Daniel Olive, Doreen A. Cantrell

    Research output: Contribution to journalArticlepeer-review

    25 Citations (Scopus)

    Abstract

    The present study compares the mitogen-activated protein (MAP) kinase responses in T cells activated with the CD28 ligands B7-1 (CD80) and B7-2/B70 (CD86). Ligands B7-1 and B7-2 do not activate the Raf-1/ERK2 cascade, but share the ability to activate related Jun kinases. These natural ligands for CD28 had no stimulatory effect alone on Jun kinase activation, but the data show that B7-1 and B7-2 could both co-operate with intracellular Ca2+ increase and protein kinase C (PKC) activation to stimulate Jun kinases. The present study shows that the interaction of CD28 with its ligands B7-1 and B7-2 can induce identical signal transduction through the MAP kinase cascades.

    Original languageEnglish
    Pages (from-to)63-70
    Number of pages8
    JournalMolecular Immunology
    Volume33
    Issue number1
    DOIs
    Publication statusPublished - Jan 1996

    Keywords

    • B7-1
    • B7-2
    • Jun kinases
    • Signal transduction

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