CD33-related sialic-acid-binding immunoglobulin-like lectins in health and disease

Sarah J. McMillan; Paul R. Crocker

doi:10.1016/j.carres.2008.01.009

CD33-related sialic-acid-binding immunoglobulin-like lectins in health and disease

Sarah J. McMillan, Paul R. Crocker

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Sialic-acid-binding immunoglobulin-like lectins (Siglecs) are members of the Ig superfamily that bind sialic acids in different linkages in a wide variety of glycoconjugates. These membrane receptors are expressed in a highly specific manner, predominantly within the haematopoietic system. The CD33-related Siglecs represent a distinct subgroup that is undergoing rapid evolution. The structural features of CD33-related Siglecs and the frequent presence of conserved cytoplasmic signalling motifs point to roles in regulating leukocyte functions that are important during inflammatory and immune responses. In this review, we summarise ligand binding preferences and describe recent progress in elucidating the functional roles of CD33-related Siglecs in the immune system. We also discuss the potential for targeting novel therapeutics against these surface receptors. (C) 2008 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	2050-2056
Number of pages	7
Journal	Carbohydrate Research
Volume	343
Issue number	12
DOIs	https://doi.org/10.1016/j.carres.2008.01.009
Publication status	Published - 11 Aug 2008

Keywords

Immunoglobulin superfamily
Inhibitory receptors
Innate immunity
Siglecs
Sialic acid
CD33
Acute myeloid leukemia
Human eosinophil apoptosis
Immune system
MSIGLEC-F
SIGLEC-F
In vivo
Mouse eosinophils
Inhibitory motif
Cells

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10.1016/j.carres.2008.01.009

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title = "CD33-related sialic-acid-binding immunoglobulin-like lectins in health and disease",

abstract = "Sialic-acid-binding immunoglobulin-like lectins (Siglecs) are members of the Ig superfamily that bind sialic acids in different linkages in a wide variety of glycoconjugates. These membrane receptors are expressed in a highly specific manner, predominantly within the haematopoietic system. The CD33-related Siglecs represent a distinct subgroup that is undergoing rapid evolution. The structural features of CD33-related Siglecs and the frequent presence of conserved cytoplasmic signalling motifs point to roles in regulating leukocyte functions that are important during inflammatory and immune responses. In this review, we summarise ligand binding preferences and describe recent progress in elucidating the functional roles of CD33-related Siglecs in the immune system. We also discuss the potential for targeting novel therapeutics against these surface receptors. (C) 2008 Elsevier Ltd. All rights reserved.",

keywords = "Immunoglobulin superfamily, Inhibitory receptors, Innate immunity, Siglecs, Sialic acid, CD33, Acute myeloid leukemia, Human eosinophil apoptosis, Immune system, MSIGLEC-F, SIGLEC-F, In vivo, Mouse eosinophils, Inhibitory motif, Cells",

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year = "2008",

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doi = "10.1016/j.carres.2008.01.009",

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journal = "Carbohydrate Research",

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T1 - CD33-related sialic-acid-binding immunoglobulin-like lectins in health and disease

AU - McMillan, Sarah J.

AU - Crocker, Paul R.

PY - 2008/8/11

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N2 - Sialic-acid-binding immunoglobulin-like lectins (Siglecs) are members of the Ig superfamily that bind sialic acids in different linkages in a wide variety of glycoconjugates. These membrane receptors are expressed in a highly specific manner, predominantly within the haematopoietic system. The CD33-related Siglecs represent a distinct subgroup that is undergoing rapid evolution. The structural features of CD33-related Siglecs and the frequent presence of conserved cytoplasmic signalling motifs point to roles in regulating leukocyte functions that are important during inflammatory and immune responses. In this review, we summarise ligand binding preferences and describe recent progress in elucidating the functional roles of CD33-related Siglecs in the immune system. We also discuss the potential for targeting novel therapeutics against these surface receptors. (C) 2008 Elsevier Ltd. All rights reserved.

AB - Sialic-acid-binding immunoglobulin-like lectins (Siglecs) are members of the Ig superfamily that bind sialic acids in different linkages in a wide variety of glycoconjugates. These membrane receptors are expressed in a highly specific manner, predominantly within the haematopoietic system. The CD33-related Siglecs represent a distinct subgroup that is undergoing rapid evolution. The structural features of CD33-related Siglecs and the frequent presence of conserved cytoplasmic signalling motifs point to roles in regulating leukocyte functions that are important during inflammatory and immune responses. In this review, we summarise ligand binding preferences and describe recent progress in elucidating the functional roles of CD33-related Siglecs in the immune system. We also discuss the potential for targeting novel therapeutics against these surface receptors. (C) 2008 Elsevier Ltd. All rights reserved.

KW - Immunoglobulin superfamily

KW - Inhibitory receptors

KW - Innate immunity

KW - Siglecs

KW - Sialic acid

KW - CD33

KW - Acute myeloid leukemia

KW - Human eosinophil apoptosis

KW - Immune system

KW - MSIGLEC-F

KW - SIGLEC-F

KW - In vivo

KW - Mouse eosinophils

KW - Inhibitory motif

KW - Cells

U2 - 10.1016/j.carres.2008.01.009

DO - 10.1016/j.carres.2008.01.009

M3 - Article

C2 - 18279844

SN - 0008-6215

VL - 343

SP - 2050

EP - 2056

JO - Carbohydrate Research

JF - Carbohydrate Research

IS - 12

ER -

CD33-related sialic-acid-binding immunoglobulin-like lectins in health and disease

Abstract

Keywords

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