Cell adhesion and epithelial differentiation

Stewart Fleming

doi:10.1002/path.1711640202

Cell adhesion and epithelial differentiation

Stewart Fleming

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

The differentiated function of epithelial tissues is dependent on the molecules which mediate the cohesion and polarization of the epithelium. Separate molecular families are responsible for the adhesion between adjacent cells and the adhesion between cells and the substratum. Using the kidney as a model of epithelial differentiation it has been shown that the assembly of a basal lamina containing the glycoprotein laminin and cadherin mediated intercellular adhesion are key events. The Wilms' tumour anti-oncogene plays a regulatory role in renal epithelial differentiation. Tissue modeling and tumour formation are both accompanied by reduced cell adhesion molecule function.

Original language	English
Pages (from-to)	95-100
Number of pages	6
Journal	Journal of Pathology
Volume	164
Issue number	2
DOIs	https://doi.org/10.1002/path.1711640202
Publication status	Published - 1991
Event	C. L. Oakley Lecture - Cambridge, United Kingdom Duration: 1 Jan 1991 → 1 Jan 1991

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10.1002/path.1711640202

C. L. Oakley Lecture Cell adhesion and epithelial differentiation
Fleming, S. (Speaker)
1991
Activity: Talk or presentation types › Invited talk

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title = "Cell adhesion and epithelial differentiation",

abstract = "The differentiated function of epithelial tissues is dependent on the molecules which mediate the cohesion and polarization of the epithelium. Separate molecular families are responsible for the adhesion between adjacent cells and the adhesion between cells and the substratum. Using the kidney as a model of epithelial differentiation it has been shown that the assembly of a basal lamina containing the glycoprotein laminin and cadherin mediated intercellular adhesion are key events. The Wilms' tumour anti-oncogene plays a regulatory role in renal epithelial differentiation. Tissue modeling and tumour formation are both accompanied by reduced cell adhesion molecule function.",

author = "Stewart Fleming",

note = "1991 C. L. Oakley Lecture delivered at the winter meeting of the Pathological Society of Great Britain and Ireland, held at the Clinical School, Addenbrooke's Hospital, University of Cambridge; C. L. Oakley Lecture ; Conference date: 01-01-1991 Through 01-01-1991",

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PY - 1991

Y1 - 1991

N2 - The differentiated function of epithelial tissues is dependent on the molecules which mediate the cohesion and polarization of the epithelium. Separate molecular families are responsible for the adhesion between adjacent cells and the adhesion between cells and the substratum. Using the kidney as a model of epithelial differentiation it has been shown that the assembly of a basal lamina containing the glycoprotein laminin and cadherin mediated intercellular adhesion are key events. The Wilms' tumour anti-oncogene plays a regulatory role in renal epithelial differentiation. Tissue modeling and tumour formation are both accompanied by reduced cell adhesion molecule function.

AB - The differentiated function of epithelial tissues is dependent on the molecules which mediate the cohesion and polarization of the epithelium. Separate molecular families are responsible for the adhesion between adjacent cells and the adhesion between cells and the substratum. Using the kidney as a model of epithelial differentiation it has been shown that the assembly of a basal lamina containing the glycoprotein laminin and cadherin mediated intercellular adhesion are key events. The Wilms' tumour anti-oncogene plays a regulatory role in renal epithelial differentiation. Tissue modeling and tumour formation are both accompanied by reduced cell adhesion molecule function.

U2 - 10.1002/path.1711640202

DO - 10.1002/path.1711640202

M3 - Article

C2 - 1649286

SN - 0022-3417

VL - 164

SP - 95

EP - 100

JO - Journal of Pathology

JF - Journal of Pathology

IS - 2

T2 - C. L. Oakley Lecture

Y2 - 1 January 1991 through 1 January 1991

ER -

Cell adhesion and epithelial differentiation

Abstract

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C. L. Oakley Lecture Cell adhesion and epithelial differentiation

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