Cell-cycle control in the face of damage - a matter of life or death

Paul R. Clarke; Lindsey A. Allan

doi:10.1016/j.tcb.2008.12.003

Cell-cycle control in the face of damage - a matter of life or death

Paul R. Clarke
, Lindsey A. Allan

Research output: Contribution to journal › Review article › peer-review

129 Citations (Scopus)

Abstract

Cells respond to DNA damage or defects in the mitotic spindle by activating checkpoints that arrest the cell cycle. Alternatively, damaged cells can undergo cell death by the process of apoptosis. The correct balance between these pathways is important for the maintenance of genomic integrity while preventing unnecessary cell death. Although the molecular mechanisms of the cell cycle and apoptosis have been elucidated, the links between them have not been clear. Recent work, however, indicates that common components directly link the regulation of apoptosis with cell-cycle checkpoints operating during interphase, whereas in mitosis, the control of apoptosis is directly coupled to the cell-cycle machinery. These findings shed new light on how the balance between cell-cycle progression and cell death is controlled.

Original language	English
Pages (from-to)	89-98
Number of pages	10
Journal	Trends in Cell Biology
Volume	19
Issue number	3
DOIs	https://doi.org/10.1016/j.tcb.2008.12.003
Publication status	Published - Mar 2009

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

SPINDLE-ASSEMBLY CHECKPOINT
DNA-DAMAGE
MITOTIC CHECKPOINT
ANTIMITOTIC DRUGS
INDUCED APOPTOSIS
CANCER-CELLS
BCL-XL
ACTIVATION
PHOSPHORYLATION
PROTEIN

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10.1016/j.tcb.2008.12.003

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title = "Cell-cycle control in the face of damage - a matter of life or death",

abstract = "Cells respond to DNA damage or defects in the mitotic spindle by activating checkpoints that arrest the cell cycle. Alternatively, damaged cells can undergo cell death by the process of apoptosis. The correct balance between these pathways is important for the maintenance of genomic integrity while preventing unnecessary cell death. Although the molecular mechanisms of the cell cycle and apoptosis have been elucidated, the links between them have not been clear. Recent work, however, indicates that common components directly link the regulation of apoptosis with cell-cycle checkpoints operating during interphase, whereas in mitosis, the control of apoptosis is directly coupled to the cell-cycle machinery. These findings shed new light on how the balance between cell-cycle progression and cell death is controlled.",

keywords = "SPINDLE-ASSEMBLY CHECKPOINT, DNA-DAMAGE, MITOTIC CHECKPOINT, ANTIMITOTIC DRUGS, INDUCED APOPTOSIS, CANCER-CELLS, BCL-XL, ACTIVATION, PHOSPHORYLATION, PROTEIN",

author = "Clarke, \{Paul R.\} and Allan, \{Lindsey A.\}",

year = "2009",

month = mar,

doi = "10.1016/j.tcb.2008.12.003",

language = "English",

volume = "19",

pages = "89--98",

journal = "Trends in Cell Biology",

issn = "0962-8924",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - Cell-cycle control in the face of damage - a matter of life or death

AU - Clarke, Paul R.

AU - Allan, Lindsey A.

PY - 2009/3

Y1 - 2009/3

N2 - Cells respond to DNA damage or defects in the mitotic spindle by activating checkpoints that arrest the cell cycle. Alternatively, damaged cells can undergo cell death by the process of apoptosis. The correct balance between these pathways is important for the maintenance of genomic integrity while preventing unnecessary cell death. Although the molecular mechanisms of the cell cycle and apoptosis have been elucidated, the links between them have not been clear. Recent work, however, indicates that common components directly link the regulation of apoptosis with cell-cycle checkpoints operating during interphase, whereas in mitosis, the control of apoptosis is directly coupled to the cell-cycle machinery. These findings shed new light on how the balance between cell-cycle progression and cell death is controlled.

AB - Cells respond to DNA damage or defects in the mitotic spindle by activating checkpoints that arrest the cell cycle. Alternatively, damaged cells can undergo cell death by the process of apoptosis. The correct balance between these pathways is important for the maintenance of genomic integrity while preventing unnecessary cell death. Although the molecular mechanisms of the cell cycle and apoptosis have been elucidated, the links between them have not been clear. Recent work, however, indicates that common components directly link the regulation of apoptosis with cell-cycle checkpoints operating during interphase, whereas in mitosis, the control of apoptosis is directly coupled to the cell-cycle machinery. These findings shed new light on how the balance between cell-cycle progression and cell death is controlled.

KW - SPINDLE-ASSEMBLY CHECKPOINT

KW - DNA-DAMAGE

KW - MITOTIC CHECKPOINT

KW - ANTIMITOTIC DRUGS

KW - INDUCED APOPTOSIS

KW - CANCER-CELLS

KW - BCL-XL

KW - ACTIVATION

KW - PHOSPHORYLATION

KW - PROTEIN

U2 - 10.1016/j.tcb.2008.12.003

DO - 10.1016/j.tcb.2008.12.003

M3 - Review article

C2 - 19168356

SN - 0962-8924

VL - 19

SP - 89

EP - 98

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 3

ER -

Cell-cycle control in the face of damage - a matter of life or death

Abstract

UN SDGs

Keywords

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