Cell cycle control of eukaryotic DNA replication

SE Kearsey; K Labib; D Maiorano

doi:10.1016/S0959-437X(96)80052-9

Cell cycle control of eukaryotic DNA replication

SE Kearsey, K Labib, D Maiorano

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

A clearer picture of replication control is emerging through the characterization of proteins, such as cdc18/Cdc6 and members of the mini-chromosome maintenance (MCM) protein family, that are involved in the initiation step. Cyclin B dependent kinases have conserved roles in both Saccharomyces cerevisiae and Schizosaccharomyces pombe, switching on DNA replication in G(1) and preventing re-replication in G(2). A model is suggested where MCMs and CDKs play complementary roles to ensure 'once-per-cell-cycle' replication, with CDKs maintaining a G(1) or GP State, whereas MCMs provide a cis-acting control on chromatin to prevent reinitiation during a single S phase.

Original language	English
Pages (from-to)	208-214
Number of pages	7
Journal	Current Opinion in Genetics & Development
Volume	6
Issue number	2
DOIs	https://doi.org/10.1016/S0959-437X(96)80052-9
Publication status	Published - Apr 1996

Keywords

LOCALIZATION
S-PHASE
SACCHAROMYCES-CEREVISIAE
MITOSIS
YEAST

Access to Document

10.1016/S0959-437X(96)80052-9

Cite this

@article{2267083c45f8443b84134f79c6d5bf3b,

title = "Cell cycle control of eukaryotic DNA replication",

abstract = "A clearer picture of replication control is emerging through the characterization of proteins, such as cdc18/Cdc6 and members of the mini-chromosome maintenance (MCM) protein family, that are involved in the initiation step. Cyclin B dependent kinases have conserved roles in both Saccharomyces cerevisiae and Schizosaccharomyces pombe, switching on DNA replication in G(1) and preventing re-replication in G(2). A model is suggested where MCMs and CDKs play complementary roles to ensure 'once-per-cell-cycle' replication, with CDKs maintaining a G(1) or GP State, whereas MCMs provide a cis-acting control on chromatin to prevent reinitiation during a single S phase.",

keywords = "LOCALIZATION, S-PHASE, SACCHAROMYCES-CEREVISIAE, MITOSIS, YEAST",

author = "SE Kearsey and K Labib and D Maiorano",

year = "1996",

month = apr,

doi = "10.1016/S0959-437X(96)80052-9",

language = "English",

volume = "6",

pages = "208--214",

journal = "Current Opinion in Genetics & Development",

issn = "0959-437X",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Cell cycle control of eukaryotic DNA replication

AU - Kearsey, SE

AU - Labib, K

AU - Maiorano, D

PY - 1996/4

Y1 - 1996/4

N2 - A clearer picture of replication control is emerging through the characterization of proteins, such as cdc18/Cdc6 and members of the mini-chromosome maintenance (MCM) protein family, that are involved in the initiation step. Cyclin B dependent kinases have conserved roles in both Saccharomyces cerevisiae and Schizosaccharomyces pombe, switching on DNA replication in G(1) and preventing re-replication in G(2). A model is suggested where MCMs and CDKs play complementary roles to ensure 'once-per-cell-cycle' replication, with CDKs maintaining a G(1) or GP State, whereas MCMs provide a cis-acting control on chromatin to prevent reinitiation during a single S phase.

AB - A clearer picture of replication control is emerging through the characterization of proteins, such as cdc18/Cdc6 and members of the mini-chromosome maintenance (MCM) protein family, that are involved in the initiation step. Cyclin B dependent kinases have conserved roles in both Saccharomyces cerevisiae and Schizosaccharomyces pombe, switching on DNA replication in G(1) and preventing re-replication in G(2). A model is suggested where MCMs and CDKs play complementary roles to ensure 'once-per-cell-cycle' replication, with CDKs maintaining a G(1) or GP State, whereas MCMs provide a cis-acting control on chromatin to prevent reinitiation during a single S phase.

KW - LOCALIZATION

KW - S-PHASE

KW - SACCHAROMYCES-CEREVISIAE

KW - MITOSIS

KW - YEAST

U2 - 10.1016/S0959-437X(96)80052-9

DO - 10.1016/S0959-437X(96)80052-9

M3 - Article

SN - 0959-437X

VL - 6

SP - 208

EP - 214

JO - Current Opinion in Genetics & Development

JF - Current Opinion in Genetics & Development

IS - 2

ER -

Cell cycle control of eukaryotic DNA replication

Abstract

Keywords

Access to Document

Fingerprint

Cite this