Cell cycle control of eukaryotic DNA replication

SE Kearsey, K Labib, D Maiorano

    Research output: Contribution to journalArticle

    22 Citations (Scopus)

    Abstract

    A clearer picture of replication control is emerging through the characterization of proteins, such as cdc18/Cdc6 and members of the mini-chromosome maintenance (MCM) protein family, that are involved in the initiation step. Cyclin B dependent kinases have conserved roles in both Saccharomyces cerevisiae and Schizosaccharomyces pombe, switching on DNA replication in G(1) and preventing re-replication in G(2). A model is suggested where MCMs and CDKs play complementary roles to ensure 'once-per-cell-cycle' replication, with CDKs maintaining a G(1) or GP State, whereas MCMs provide a cis-acting control on chromatin to prevent reinitiation during a single S phase.

    Original languageEnglish
    Pages (from-to)208-214
    Number of pages7
    JournalCurrent Opinion in Genetics & Development
    Volume6
    Issue number2
    DOIs
    Publication statusPublished - Apr 1996

    Keywords

    • LOCALIZATION
    • S-PHASE
    • SACCHAROMYCES-CEREVISIAE
    • MITOSIS
    • YEAST

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