Cell cycle control of replication initiation in eukaryotes

Stephane Chevalier; J. Julian Blow

doi:10.1016/S0955-0674(96)80082-2

Cell cycle control of replication initiation in eukaryotes

Stephane Chevalier, J. Julian Blow

Research output: Contribution to journal › Article › peer-review

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Abstract

Studies on the initiation of DNA replication in eukaryotes have progressed recently through different approaches that promise to converge. Proteins interacting with the origin recognition complex form a prereplicative complex early in the cell cycle. The regulation of the binding of MCM/P1 proteins to chromatin plays a key role in the replication licensing system which prevents re-replication in a single cell cycle. Cyclin-dependent kinases provide an overall control of the cell cycle by stimulating S-phase entry and possibly by preventing re-establishment of prereplicative complexes in G2 phase.

Original language	English
Pages (from-to)	815-821
Number of pages	7
Journal	Current Opinion in Cell Biology
Volume	8
Issue number	6
DOIs	https://doi.org/10.1016/S0955-0674(96)80082-2
Publication status	Published - Dec 1996

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title = "Cell cycle control of replication initiation in eukaryotes",

abstract = "Studies on the initiation of DNA replication in eukaryotes have progressed recently through different approaches that promise to converge. Proteins interacting with the origin recognition complex form a prereplicative complex early in the cell cycle. The regulation of the binding of MCM/P1 proteins to chromatin plays a key role in the replication licensing system which prevents re-replication in a single cell cycle. Cyclin-dependent kinases provide an overall control of the cell cycle by stimulating S-phase entry and possibly by preventing re-establishment of prereplicative complexes in G2 phase.",

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AU - Blow, J. Julian

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AB - Studies on the initiation of DNA replication in eukaryotes have progressed recently through different approaches that promise to converge. Proteins interacting with the origin recognition complex form a prereplicative complex early in the cell cycle. The regulation of the binding of MCM/P1 proteins to chromatin plays a key role in the replication licensing system which prevents re-replication in a single cell cycle. Cyclin-dependent kinases provide an overall control of the cell cycle by stimulating S-phase entry and possibly by preventing re-establishment of prereplicative complexes in G2 phase.

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DO - 10.1016/S0955-0674(96)80082-2

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VL - 8

SP - 815

EP - 821

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

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ER -

Cell cycle control of replication initiation in eukaryotes

Abstract

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