Cell cycle control of replication initiation in eukaryotes

TY - JOUR

T1 - Cell cycle control of replication initiation in eukaryotes

AU - Chevalier, Stephane

AU - Blow, J. Julian

PY - 1996/12

Y1 - 1996/12

N2 - Studies on the initiation of DNA replication in eukaryotes have progressed recently through different approaches that promise to converge. Proteins interacting with the origin recognition complex form a prereplicative complex early in the cell cycle. The regulation of the binding of MCM/P1 proteins to chromatin plays a key role in the replication licensing system which prevents re-replication in a single cell cycle. Cyclin-dependent kinases provide an overall control of the cell cycle by stimulating S-phase entry and possibly by preventing re-establishment of prereplicative complexes in G2 phase.

AB - Studies on the initiation of DNA replication in eukaryotes have progressed recently through different approaches that promise to converge. Proteins interacting with the origin recognition complex form a prereplicative complex early in the cell cycle. The regulation of the binding of MCM/P1 proteins to chromatin plays a key role in the replication licensing system which prevents re-replication in a single cell cycle. Cyclin-dependent kinases provide an overall control of the cell cycle by stimulating S-phase entry and possibly by preventing re-establishment of prereplicative complexes in G2 phase.

U2 - 10.1016/S0955-0674(96)80082-2

DO - 10.1016/S0955-0674(96)80082-2

M3 - Article

C2 - 8939667

SN - 0955-0674

VL - 8

SP - 815

EP - 821

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

IS - 6

ER -