Cell Cycle Entry Control in Naïve and Memory CD8+ T Cells

David A. Lewis (Lead / Corresponding author), Tony Ly

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)
17 Downloads (Pure)

Abstract

CD8+ T cells play important roles in immunity and immuno-oncology. Upon antigen recognition and co-stimulation, naïve CD8+ T cells escape from dormancy to engage in a complex programme of cellular growth, cell cycle entry and differentiation, resulting in rapid proliferation cycles that has the net effect of producing clonally expanded, antigen-specific cytotoxic T lymphocytes (CTLs). A fraction of activated T cells will re-enter dormancy by differentiating into memory T cells, which have essential roles in adaptive immunity. In this review, we discuss the current understanding of cell cycle entry control in CD8+ T cells and crosstalk between these mechanisms and pathways regulating immunological phenotypes.

Original languageEnglish
Article number727441
Number of pages10
JournalFrontiers in Cell and Developmental Biology
Volume9
DOIs
Publication statusPublished - 6 Oct 2021

Keywords

  • cell cycle
  • proliferation
  • quiescence
  • T cell
  • T cell activation

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