Cell Cycle Entry Control in Naïve and Memory CD8+ T Cells

David A. Lewis (Lead / Corresponding author), Tony Ly

    Research output: Contribution to journalReview articlepeer-review

    8 Citations (Scopus)
    55 Downloads (Pure)

    Abstract

    CD8+ T cells play important roles in immunity and immuno-oncology. Upon antigen recognition and co-stimulation, naïve CD8+ T cells escape from dormancy to engage in a complex programme of cellular growth, cell cycle entry and differentiation, resulting in rapid proliferation cycles that has the net effect of producing clonally expanded, antigen-specific cytotoxic T lymphocytes (CTLs). A fraction of activated T cells will re-enter dormancy by differentiating into memory T cells, which have essential roles in adaptive immunity. In this review, we discuss the current understanding of cell cycle entry control in CD8+ T cells and crosstalk between these mechanisms and pathways regulating immunological phenotypes.

    Original languageEnglish
    Article number727441
    Number of pages10
    JournalFrontiers in Cell and Developmental Biology
    Volume9
    DOIs
    Publication statusPublished - 6 Oct 2021

    Keywords

    • cell cycle
    • proliferation
    • quiescence
    • T cell
    • T cell activation

    ASJC Scopus subject areas

    • Developmental Biology
    • Cell Biology

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