Cell Cycle Entry Control in Naïve and Memory CD8+ T Cells

David A. Lewis; Tony Ly

doi:10.3389/fcell.2021.727441

Cell Cycle Entry Control in Naïve and Memory CD8⁺ T Cells

David A. Lewis (Lead / Corresponding author)
, Tony Ly

Research output: Contribution to journal › Review article › peer-review

17 Citations (Scopus)

134 Downloads (Pure)

Abstract

CD8⁺ T cells play important roles in immunity and immuno-oncology. Upon antigen recognition and co-stimulation, naïve CD8⁺ T cells escape from dormancy to engage in a complex programme of cellular growth, cell cycle entry and differentiation, resulting in rapid proliferation cycles that has the net effect of producing clonally expanded, antigen-specific cytotoxic T lymphocytes (CTLs). A fraction of activated T cells will re-enter dormancy by differentiating into memory T cells, which have essential roles in adaptive immunity. In this review, we discuss the current understanding of cell cycle entry control in CD8⁺ T cells and crosstalk between these mechanisms and pathways regulating immunological phenotypes.

Original language	English
Article number	727441
Number of pages	10
Journal	Frontiers in Cell and Developmental Biology
Volume	9
DOIs	https://doi.org/10.3389/fcell.2021.727441
Publication status	Published - 6 Oct 2021

Keywords

cell cycle
proliferation
quiescence
T cell
T cell activation

ASJC Scopus subject areas

Developmental Biology
Cell Biology

Access to Document

10.3389/fcell.2021.727441Licence: CC BY

Final Published VersionFinal published version, 1.44 MBLicence: CC BY

Cite this

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title = "Cell Cycle Entry Control in Na{\"i}ve and Memory CD8+ T Cells",

abstract = "CD8+ T cells play important roles in immunity and immuno-oncology. Upon antigen recognition and co-stimulation, na{\"i}ve CD8+ T cells escape from dormancy to engage in a complex programme of cellular growth, cell cycle entry and differentiation, resulting in rapid proliferation cycles that has the net effect of producing clonally expanded, antigen-specific cytotoxic T lymphocytes (CTLs). A fraction of activated T cells will re-enter dormancy by differentiating into memory T cells, which have essential roles in adaptive immunity. In this review, we discuss the current understanding of cell cycle entry control in CD8+ T cells and crosstalk between these mechanisms and pathways regulating immunological phenotypes.",

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author = "Lewis, \{David A.\} and Tony Ly",

note = "Funding Information: TL was supported by a Sir Henry Dale Fellowship funded by the Wellcome Trust and the Royal Society (206211/A/17/Z). DL was supported by a BBSRC EASTBIO Ph.D. Studentship. Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Lewis and Ly.",

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doi = "10.3389/fcell.2021.727441",

language = "English",

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T1 - Cell Cycle Entry Control in Naïve and Memory CD8+ T Cells

AU - Lewis, David A.

AU - Ly, Tony

N1 - Funding Information: TL was supported by a Sir Henry Dale Fellowship funded by the Wellcome Trust and the Royal Society (206211/A/17/Z). DL was supported by a BBSRC EASTBIO Ph.D. Studentship. Publisher Copyright: © Copyright © 2021 Lewis and Ly.

PY - 2021/10/6

Y1 - 2021/10/6

N2 - CD8+ T cells play important roles in immunity and immuno-oncology. Upon antigen recognition and co-stimulation, naïve CD8+ T cells escape from dormancy to engage in a complex programme of cellular growth, cell cycle entry and differentiation, resulting in rapid proliferation cycles that has the net effect of producing clonally expanded, antigen-specific cytotoxic T lymphocytes (CTLs). A fraction of activated T cells will re-enter dormancy by differentiating into memory T cells, which have essential roles in adaptive immunity. In this review, we discuss the current understanding of cell cycle entry control in CD8+ T cells and crosstalk between these mechanisms and pathways regulating immunological phenotypes.

AB - CD8+ T cells play important roles in immunity and immuno-oncology. Upon antigen recognition and co-stimulation, naïve CD8+ T cells escape from dormancy to engage in a complex programme of cellular growth, cell cycle entry and differentiation, resulting in rapid proliferation cycles that has the net effect of producing clonally expanded, antigen-specific cytotoxic T lymphocytes (CTLs). A fraction of activated T cells will re-enter dormancy by differentiating into memory T cells, which have essential roles in adaptive immunity. In this review, we discuss the current understanding of cell cycle entry control in CD8+ T cells and crosstalk between these mechanisms and pathways regulating immunological phenotypes.

KW - cell cycle

KW - proliferation

KW - quiescence

KW - T cell

KW - T cell activation

UR - https://www.scopus.com/pages/publications/85117448800

U2 - 10.3389/fcell.2021.727441

DO - 10.3389/fcell.2021.727441

M3 - Review article

C2 - 34692683

AN - SCOPUS:85117448800

SN - 2296-634X

VL - 9

JO - Frontiers in Cell and Developmental Biology

JF - Frontiers in Cell and Developmental Biology

M1 - 727441

ER -

Cell Cycle Entry Control in Naïve and Memory CD8⁺ T Cells

Abstract

Keywords

ASJC Scopus subject areas

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Understanding the Proliferation-Quiescence Switch Using Quantitative Cellular Biochemistry (Sir Henry Dale Fellowship) (Transfer from University of Edinburgh)

Cite this

Cell Cycle Entry Control in Naïve and Memory CD8+ T Cells

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Projects

Understanding the Proliferation-Quiescence Switch Using Quantitative Cellular Biochemistry (Sir Henry Dale Fellowship) (Transfer from University of Edinburgh)

Cite this

Cell Cycle Entry Control in Naïve and Memory CD8⁺ T Cells