Cell cycle progression in response to oxygen levels

Brian Ortmann, Jimena Druker, Sonia Rocha (Lead / Corresponding author)

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Hypoxia, or decreases in oxygen availability, results in the activation of a number of different responses at both the whole organism and the cellular level. These responses include drastic changes in gene expression, which allow the organism (or cell) to cope efficiently with the stresses associated with the hypoxic insult. A major breakthrough in the understanding of the cellular response to hypoxia was the discovery of a hypoxia sensitive family of transcription factors known as the hypoxia inducible factors (HIFs). The hypoxia response mounted by the HIFs promotes cell survival and energy conservation. As such, this response has to deal with important cellular process such as cell division. In this review, the integration of oxygen sensing with the cell cycle will be discussed. HIFs, as well as other components of the hypoxia pathway, can influence cell cycle progression. The role of HIF and the cell molecular oxygen sensors in the control of the cell cycle will be reviewed.
Original languageEnglish
Pages (from-to)3569-3582
Number of pages14
JournalCellular and Molecular Life Sciences
Volume71
Issue number18
Early online date25 May 2014
DOIs
Publication statusPublished - Sep 2014

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