Cell cycle RNA regulons coordinating early lymphocyte development

Alison Galloway, Martin Turner (Lead / Corresponding author)

Research output: Contribution to journalArticle

4 Citations (Scopus)
64 Downloads (Pure)

Abstract

Lymphocytes undergo dynamic changes in gene expression as they develop from progenitor cells lacking antigen receptors, to mature cells that are prepared to mount immune responses. While transcription factors have established roles in lymphocyte development, they act in concert with post-transcriptional and post-translational regulators to determine the proteome. Furthermore, the post-transcriptional regulation of RNA regulons consisting of mRNAs whose protein products act cooperatively allows RNA binding proteins to exert their effects at multiple points in a pathway. Here, we review recent evidence demonstrating the importance of RNA binding proteins that control the cell cycle in lymphocyte development and discuss the implications for tumorigenesis. For further resources related to this article, please visit the WIREs website.

Original languageEnglish
Article numbere1419
Pages (from-to)1-15
Number of pages15
JournalWiley Interdisciplinary Reviews: RNA
Volume8
Issue number5
Early online date23 Feb 2017
DOIs
Publication statusPublished - 2017

Fingerprint

Regulon
Lymphocytes
Cell Cycle
RNA-Binding Proteins
Cells
RNA
Antigen Receptors
Proteome
Cell Cycle Checkpoints
Gene expression
Websites
Carcinogenesis
Transcription Factors
Stem Cells
Gene Expression
Messenger RNA
Proteins

Keywords

  • Journal article
  • Review

Cite this

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title = "Cell cycle RNA regulons coordinating early lymphocyte development",
abstract = "Lymphocytes undergo dynamic changes in gene expression as they develop from progenitor cells lacking antigen receptors, to mature cells that are prepared to mount immune responses. While transcription factors have established roles in lymphocyte development, they act in concert with post-transcriptional and post-translational regulators to determine the proteome. Furthermore, the post-transcriptional regulation of RNA regulons consisting of mRNAs whose protein products act cooperatively allows RNA binding proteins to exert their effects at multiple points in a pathway. Here, we review recent evidence demonstrating the importance of RNA binding proteins that control the cell cycle in lymphocyte development and discuss the implications for tumorigenesis. For further resources related to this article, please visit the WIREs website.",
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author = "Alison Galloway and Martin Turner",
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Cell cycle RNA regulons coordinating early lymphocyte development. / Galloway, Alison; Turner, Martin (Lead / Corresponding author).

In: Wiley Interdisciplinary Reviews: RNA, Vol. 8, No. 5, e1419, 2017, p. 1-15.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cell cycle RNA regulons coordinating early lymphocyte development

AU - Galloway, Alison

AU - Turner, Martin

N1 - Work in the Turner Laboratory is supported by the Biotechnology and Biological Sciences Research Council. AG was supported by funding from Bloodwise.

PY - 2017

Y1 - 2017

N2 - Lymphocytes undergo dynamic changes in gene expression as they develop from progenitor cells lacking antigen receptors, to mature cells that are prepared to mount immune responses. While transcription factors have established roles in lymphocyte development, they act in concert with post-transcriptional and post-translational regulators to determine the proteome. Furthermore, the post-transcriptional regulation of RNA regulons consisting of mRNAs whose protein products act cooperatively allows RNA binding proteins to exert their effects at multiple points in a pathway. Here, we review recent evidence demonstrating the importance of RNA binding proteins that control the cell cycle in lymphocyte development and discuss the implications for tumorigenesis. For further resources related to this article, please visit the WIREs website.

AB - Lymphocytes undergo dynamic changes in gene expression as they develop from progenitor cells lacking antigen receptors, to mature cells that are prepared to mount immune responses. While transcription factors have established roles in lymphocyte development, they act in concert with post-transcriptional and post-translational regulators to determine the proteome. Furthermore, the post-transcriptional regulation of RNA regulons consisting of mRNAs whose protein products act cooperatively allows RNA binding proteins to exert their effects at multiple points in a pathway. Here, we review recent evidence demonstrating the importance of RNA binding proteins that control the cell cycle in lymphocyte development and discuss the implications for tumorigenesis. For further resources related to this article, please visit the WIREs website.

KW - Journal article

KW - Review

U2 - 10.1002/wrna.1419

DO - 10.1002/wrna.1419

M3 - Article

VL - 8

SP - 1

EP - 15

JO - Wiley Interdisciplinary Reviews: RNA

JF - Wiley Interdisciplinary Reviews: RNA

SN - 1757-7004

IS - 5

M1 - e1419

ER -