Cell cycle RNA regulons coordinating early lymphocyte development

Alison Galloway, Martin Turner (Lead / Corresponding author)

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    Lymphocytes undergo dynamic changes in gene expression as they develop from progenitor cells lacking antigen receptors, to mature cells that are prepared to mount immune responses. While transcription factors have established roles in lymphocyte development, they act in concert with post-transcriptional and post-translational regulators to determine the proteome. Furthermore, the post-transcriptional regulation of RNA regulons consisting of mRNAs whose protein products act cooperatively allows RNA binding proteins to exert their effects at multiple points in a pathway. Here, we review recent evidence demonstrating the importance of RNA binding proteins that control the cell cycle in lymphocyte development and discuss the implications for tumorigenesis. For further resources related to this article, please visit the WIREs website.

    Original languageEnglish
    Article numbere1419
    Pages (from-to)1-15
    Number of pages15
    JournalWiley Interdisciplinary Reviews: RNA
    Issue number5
    Early online date23 Feb 2017
    Publication statusPublished - 2017


    • Journal article
    • Review


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