Cell cycle RNA regulons coordinating early lymphocyte development

Alison Galloway, Martin Turner (Lead / Corresponding author)

Research output: Contribution to journalArticle

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Abstract

Lymphocytes undergo dynamic changes in gene expression as they develop from progenitor cells lacking antigen receptors, to mature cells that are prepared to mount immune responses. While transcription factors have established roles in lymphocyte development, they act in concert with post-transcriptional and post-translational regulators to determine the proteome. Furthermore, the post-transcriptional regulation of RNA regulons consisting of mRNAs whose protein products act cooperatively allows RNA binding proteins to exert their effects at multiple points in a pathway. Here, we review recent evidence demonstrating the importance of RNA binding proteins that control the cell cycle in lymphocyte development and discuss the implications for tumorigenesis. For further resources related to this article, please visit the WIREs website.

Original languageEnglish
Article numbere1419
Pages (from-to)1-15
Number of pages15
JournalWiley Interdisciplinary Reviews: RNA
Volume8
Issue number5
Early online date23 Feb 2017
DOIs
Publication statusPublished - 2017

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Keywords

  • Journal article
  • Review

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