Cell growth effects of Epstein-Barr virus leader protein

Gordon J. Allan, Gareth J. Inman, Bruce D. Parker, David T. Rowe, Paul J. Farrell

    Research output: Contribution to journalArticlepeer-review

    41 Citations (Scopus)

    Abstract

    B lymphoblastoid cell lines immortalized with P3HR1/633 Epstein-Barr virus (EBV), which has a deletion in the EBV nuclear antigen leader protein (EBNA-LP) gene, were transfected with a vector expressing wild-type EBNA-LP. The EBNA-LP transfectants grew out faster under G418 selection than control cells but expression of EBNA-LP made no significant difference to growth rate or saturation density of the resulting established cell lines. When the cells expressing EBNA-LP were allowed to grow to saturation and then diluted in fresh medium they underwent DNA synthesis more rapidly than control cultures.
    Original languageEnglish
    Pages (from-to)1547-1551
    Number of pages5
    JournalJournal of General Virology
    Volume73
    Issue number6
    DOIs
    Publication statusPublished - 1992

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