Cell movement patterns during gastrulation in the chick are controlled by positive and negative chemotaxis mediated by FGF4 and FGF8

Xuesong Yang, Dirk Dormann, Andrea E. Munsterberg, Cornelis J. Weijer

    Research output: Contribution to journalArticle

    227 Citations (Scopus)

    Abstract

    During gastrulation in amniotes, epiblast cells ingress through the primitive streak and migrate away to form endodermal, mesodermal, and extraembryonic structures. Here we analyze the detailed movement trajectories of cells emerging at different anterior-posterior positions from the primitive streak, using in vivo imaging of the movement of GFP-tagged streak cells. Cells emerging at different anterior-posterior positions from the streak show characteristic cell migration patterns, in response to guidance signals from neighboring tissues. Streak cells are attracted by sources of FGF4 and repelled by sources of FGF8. The observed movement patterns of anterior streak cells can be explained by an FGF8-mediated chemorepulsion of cells away from the streak followed by chemoattraction toward an FGF4 signal produced by the forming notochord.
    Original languageEnglish
    Pages (from-to)425-437
    Number of pages13
    JournalDevelopmental Cell
    Volume3
    Issue number3
    DOIs
    Publication statusPublished - 2002

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    Gastrulation
    Chemotaxis
    Cell Movement
    Primitive Streak
    Notochord
    Germ Layers

    Cite this

    @article{1e3eaeee3d6d4e71af5f6efb299546d3,
    title = "Cell movement patterns during gastrulation in the chick are controlled by positive and negative chemotaxis mediated by FGF4 and FGF8",
    abstract = "During gastrulation in amniotes, epiblast cells ingress through the primitive streak and migrate away to form endodermal, mesodermal, and extraembryonic structures. Here we analyze the detailed movement trajectories of cells emerging at different anterior-posterior positions from the primitive streak, using in vivo imaging of the movement of GFP-tagged streak cells. Cells emerging at different anterior-posterior positions from the streak show characteristic cell migration patterns, in response to guidance signals from neighboring tissues. Streak cells are attracted by sources of FGF4 and repelled by sources of FGF8. The observed movement patterns of anterior streak cells can be explained by an FGF8-mediated chemorepulsion of cells away from the streak followed by chemoattraction toward an FGF4 signal produced by the forming notochord.",
    author = "Xuesong Yang and Dirk Dormann and Munsterberg, {Andrea E.} and Weijer, {Cornelis J.}",
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    Cell movement patterns during gastrulation in the chick are controlled by positive and negative chemotaxis mediated by FGF4 and FGF8. / Yang, Xuesong; Dormann, Dirk; Munsterberg, Andrea E.; Weijer, Cornelis J.

    In: Developmental Cell, Vol. 3, No. 3, 2002, p. 425-437.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Cell movement patterns during gastrulation in the chick are controlled by positive and negative chemotaxis mediated by FGF4 and FGF8

    AU - Yang, Xuesong

    AU - Dormann, Dirk

    AU - Munsterberg, Andrea E.

    AU - Weijer, Cornelis J.

    N1 - dc.publisher: Elsevier

    PY - 2002

    Y1 - 2002

    N2 - During gastrulation in amniotes, epiblast cells ingress through the primitive streak and migrate away to form endodermal, mesodermal, and extraembryonic structures. Here we analyze the detailed movement trajectories of cells emerging at different anterior-posterior positions from the primitive streak, using in vivo imaging of the movement of GFP-tagged streak cells. Cells emerging at different anterior-posterior positions from the streak show characteristic cell migration patterns, in response to guidance signals from neighboring tissues. Streak cells are attracted by sources of FGF4 and repelled by sources of FGF8. The observed movement patterns of anterior streak cells can be explained by an FGF8-mediated chemorepulsion of cells away from the streak followed by chemoattraction toward an FGF4 signal produced by the forming notochord.

    AB - During gastrulation in amniotes, epiblast cells ingress through the primitive streak and migrate away to form endodermal, mesodermal, and extraembryonic structures. Here we analyze the detailed movement trajectories of cells emerging at different anterior-posterior positions from the primitive streak, using in vivo imaging of the movement of GFP-tagged streak cells. Cells emerging at different anterior-posterior positions from the streak show characteristic cell migration patterns, in response to guidance signals from neighboring tissues. Streak cells are attracted by sources of FGF4 and repelled by sources of FGF8. The observed movement patterns of anterior streak cells can be explained by an FGF8-mediated chemorepulsion of cells away from the streak followed by chemoattraction toward an FGF4 signal produced by the forming notochord.

    U2 - doi:10.1016/S1534-5807(02)00256-3

    DO - doi:10.1016/S1534-5807(02)00256-3

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    JO - Developmental Cell

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