Cell regulation by the Apc protein: Apc as master regulator of epithelia

Brooke M. McCartney, Inke S. Nathke

    Research output: Contribution to journalArticle

    105 Citations (Scopus)

    Abstract

    The adenomatous polyposis coli (Apc) protein participates in many of the fundamental cellular processes that govern epithelial tissues: Apc is directly involved in regulating the availability of beta-catenin for transcriptional cle-repression of Tcf/ LEF transcription factors, it contributes to the stability of microtubules in interphase and mitosis, and has an impact on the dynamics of F-actin. Thus Apc contributes directly and/or indirectly to proliferation, differentiation, migration, and apoptosis. This particular multifunctionality can explain why disruption of Apc is especially detrimental for the epithelium of the gut, where Apc mutations are common in most cancers. We summarise recent data that shed light on the molecular mechanisms involved in the different functions of Apc.

    Original languageEnglish
    Pages (from-to)186-193
    Number of pages8
    JournalCurrent Opinion in Cell Biology
    Volume20
    Issue number2
    DOIs
    Publication statusPublished - Apr 2008

    Keywords

    • Adenomatous polyposis coli
    • Beta catenin degradation
    • Tumor suppressor Apc
    • Phosphotase
    • Gene product
    • In vivo
    • Microtubule stability
    • Crystal structure
    • Drosophila APC2
    • Small intestine

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