Cell size control - a mechanism for maintaining fitness and function

Teemu P. Miettinen, Matias J. Caldez, Philipp Kaldis, Mikael Björklund (Lead / Corresponding author)

    Research output: Contribution to journalArticlepeer-review

    46 Citations (Scopus)

    Abstract

    The maintenance of cell size homeostasis has been studied for years in different cellular systems. With the focus on 'what regulates cell size', the question 'why cell size needs to be maintained' has been largely overlooked. Recent evidence indicates that animal cells exhibit nonlinear cell size dependent growth rates and mitochondrial metabolism, which are maximal in intermediate sized cells within each cell population. Increases in intracellular distances and changes in the relative cell surface area impose biophysical limitations on cells, which can explain why growth and metabolic rates are maximal in a specific cell size range. Consistently, aberrant increases in cell size, for example through polyploidy, are typically disadvantageous to cellular metabolism, fitness and functionality. Accordingly, cellular hypertrophy can potentially predispose to or worsen metabolic diseases. We propose that cell size control may have emerged as a guardian of cellular fitness and metabolic activity.

    Original languageEnglish
    Article number1700058
    Pages (from-to)1-12
    Number of pages12
    JournalBioEssays
    Volume39
    Issue number9
    Early online date28 Jul 2017
    DOIs
    Publication statusPublished - 23 Aug 2017

    Keywords

    • Journal article
    • Cell size control
    • Fitness
    • Metabolism
    • Mevalonate pathway
    • Mitochondria
    • Polyploidy
    • Statin

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