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Cellular modelling of Type IA PI3K dynamics in health and disease
Ralitsa Madsen
MRC PPU
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peer-review
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Keyphrases
Activating mutation
12%
Cas9 Protein
12%
Cell Modeling
100%
Disease Heterogeneity
12%
Disease Model
12%
Dynamic Encoding
12%
Early Onset
12%
Founder mutation
12%
Gene Editing
12%
Human Disease
12%
Hyperactivity
12%
Induced Pluripotent Stem Cells (iPSCs)
12%
Isogenic
12%
Kinase Activation
12%
Kinase Activity
12%
Kinase Signaling
25%
Optogenetics
12%
P110α
25%
Phenotypic Variation
12%
Phosphoinositide 3-kinase (PI3K)
100%
PIK3CA
12%
PIK3CA mutation
25%
Reverse Phase Protein Array
12%
Segmental Overgrowth
12%
Signaling Network
12%
Signalome
12%
Spatiotemporal Control
12%
Targeted Therapy
12%
Temporal Patterns
12%
Biochemistry, Genetics and Molecular Biology
CRISPR/Cas9
12%
Dynamics
100%
Genome Editing
12%
Human Induced Pluripotent Stem Cell
12%
Mosaicism
12%
Optogenetics
12%
Phosphoinositide 3-Kinase
100%
Protein Microarray
12%