Cellular processes driving gastrulation in the avian embryo

Guillermo Serrano Nájera, Cornelis J. Weijer (Lead / Corresponding author)

Research output: Contribution to journalReview article

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Abstract

Gastrulation consists in the dramatic reorganisation of the epiblast, a one-cell thick epithelial sheet, into a multilayered embryo. In chick, the formation of the internal layers requires the generation of a macroscopic convection-like flow, which involves up to 50,000 epithelial cells in the epiblast. These cell movements locate the mesendoderm precursors into the midline of the epiblast to form the primitive streak. There they acquire a mesenchymal phenotype, ingress into the embryo and migrate outward to populate the inner embryonic layers. This review covers what is currently understood about how cell behaviours ultimately cause these morphogenetic events and how they are regulated. We discuss 1) how the biochemical patterning of the embryo before gastrulation creates compartments of differential cell behaviours, 2) how the global epithelial flows arise from the coordinated actions of individual cells, 3) how the cells delaminate individually from the epiblast during the ingression, and 4) how cells move after the ingression following stereotypical migration routes. We conclude by exploring new technical advances that will facilitate future research in the chick model system.

Original languageEnglish
Article number103624
Pages (from-to)1-14
Number of pages14
JournalMechanisms of Development
Volume163
Early online date17 Jun 2020
DOIs
Publication statusE-pub ahead of print - 17 Jun 2020

Keywords

  • Cell flows
  • Chick embryo
  • Gastrulation
  • Intercalation
  • Morphogenesis
  • Patterning

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