Cellular senescence and cardiovascular diseases: moving to the "heart" of the problem

Konstantinos Evangelou, Panagiotis V. S. Vasileiou, Angelos Papaspyropoulos, Orsalia Hazapis, Russell Petty, Marco Demaria, Vassilis G. Gorgoulis (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Cardiovascular diseases (CVDs) constitute the prime cause of global mortality, with an immense impact on patient quality of life and disability. Clinical evidence has revealed a strong connection between cellular senescence and worse cardiac outcomes in the majority of CVDs concerning both ischemic and nonischemic cardiomyopathies. Cellular senescence is characterized by cell cycle arrest accompanied by alterations in several metabolic pathways, resulting in morphological and functional changes. Metabolic rewiring of senescent cells results in marked paracrine activity, through a unique secretome, often exerting deleterious effects on neighboring cells. Here, we recapitulate the hallmarks and key molecular pathways involved in cellular senescence in the cardiac context and summarize the different roles of senescence in the majority of CVDs. In the last few years, the possibility of eliminating senescent cells in various pathological conditions has been increasingly explored, giving rise to the field of senotherapeutics. Therefore, we additionally attempt to clarify the current state of this field with a focus on cardiac senescence and discuss the potential of implementing senolytics as a treatment option in heart disease.

Original languageEnglish
Pages (from-to)609-647
Number of pages39
JournalPhysiological Reviews
Volume103
Issue number1
Early online date1 Sep 2022
DOIs
Publication statusE-pub ahead of print - 1 Sep 2022

Keywords

  • Cardiovascular diseases
  • stress
  • cellular senescence
  • senotherapeutics
  • cardiovascular diseases

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