Cellularity and the quantitation of estrogen receptors

R. C. Mason; R. J. C. Steele; R. A. Hawkins; W. R. Miller; A. P. M. Forrest

doi:10.1007/BF01806936

Cellularity and the quantitation of estrogen receptors

R. C. Mason, R. J. C. Steele, R. A. Hawkins, W. R. Miller, A. P. M. Forrest

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Fifty estrogen receptor (ER)-positive breast cancers have been studied to determine the best way of correcting for differences in cellularity when expressing ER concentration. ER concentration expressed on wet weight and tumour cytosol protein bases showed a positive correlation with tumour cellularity. In contrast, ER concentrations expressed on a DNA basis were not significantly related to cellularity. Although such a mode of correcting for differences in cellularity was imperfect, it did yield a receptor concentration which was less dependent upon tissue cellularity and which may reflect more accurately the inherent receptor status of the tumour cells.

Original language	English
Pages (from-to)	239-42
Number of pages	4
Journal	Breast Cancer Research and Treatment
Volume	2
Issue number	3
DOIs	https://doi.org/10.1007/BF01806936
Publication status	Published - 1 Sept 1982

Keywords

Breast Neoplasms
Cytosol
DNA, Neoplasm
Female
Humans
Menopause
Neoplasm Proteins
Receptors, Estrogen

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF01806936

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title = "Cellularity and the quantitation of estrogen receptors",

abstract = "Fifty estrogen receptor (ER)-positive breast cancers have been studied to determine the best way of correcting for differences in cellularity when expressing ER concentration. ER concentration expressed on wet weight and tumour cytosol protein bases showed a positive correlation with tumour cellularity. In contrast, ER concentrations expressed on a DNA basis were not significantly related to cellularity. Although such a mode of correcting for differences in cellularity was imperfect, it did yield a receptor concentration which was less dependent upon tissue cellularity and which may reflect more accurately the inherent receptor status of the tumour cells.",

keywords = "Breast Neoplasms, Cytosol, DNA, Neoplasm, Female, Humans, Menopause, Neoplasm Proteins, Receptors, Estrogen",

author = "Mason, {R. C.} and Steele, {R. J. C.} and Hawkins, {R. A.} and Miller, {W. R.} and Forrest, {A. P. M.}",

year = "1982",

month = sep,

day = "1",

doi = "10.1007/BF01806936",

language = "English",

volume = "2",

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journal = "Breast Cancer Research and Treatment",

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TY - JOUR

T1 - Cellularity and the quantitation of estrogen receptors

AU - Mason, R. C.

AU - Steele, R. J. C.

AU - Hawkins, R. A.

AU - Miller, W. R.

AU - Forrest, A. P. M.

PY - 1982/9/1

Y1 - 1982/9/1

N2 - Fifty estrogen receptor (ER)-positive breast cancers have been studied to determine the best way of correcting for differences in cellularity when expressing ER concentration. ER concentration expressed on wet weight and tumour cytosol protein bases showed a positive correlation with tumour cellularity. In contrast, ER concentrations expressed on a DNA basis were not significantly related to cellularity. Although such a mode of correcting for differences in cellularity was imperfect, it did yield a receptor concentration which was less dependent upon tissue cellularity and which may reflect more accurately the inherent receptor status of the tumour cells.

AB - Fifty estrogen receptor (ER)-positive breast cancers have been studied to determine the best way of correcting for differences in cellularity when expressing ER concentration. ER concentration expressed on wet weight and tumour cytosol protein bases showed a positive correlation with tumour cellularity. In contrast, ER concentrations expressed on a DNA basis were not significantly related to cellularity. Although such a mode of correcting for differences in cellularity was imperfect, it did yield a receptor concentration which was less dependent upon tissue cellularity and which may reflect more accurately the inherent receptor status of the tumour cells.

KW - Breast Neoplasms

KW - Cytosol

KW - DNA, Neoplasm

KW - Female

KW - Humans

KW - Menopause

KW - Neoplasm Proteins

KW - Receptors, Estrogen

U2 - 10.1007/BF01806936

DO - 10.1007/BF01806936

M3 - Article

C2 - 7150778

SN - 0167-6806

VL - 2

SP - 239

EP - 242

JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

IS - 3

ER -

Cellularity and the quantitation of estrogen receptors

Abstract

Keywords

UN SDGs

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