Central nervous system regeneration is driven by microglia necroptosis and repopulation

Amy F. Lloyd, Claire L. Davies, Rebecca K. Holloway, Yasmine Labrak, Graeme Ireland, Dario Carradori, Alessandra Dillenburg, Eva Borger, Daniel Soong, Jill C. Richardson, Tanja Kuhlmann, Anna Williams, Jeffrey W. Pollard, Anne des Rieux, Josef Priller, Veronique E. Miron (Lead / Corresponding author)

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26 Citations (Scopus)
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Abstract

Failed regeneration of CNS myelin contributes to clinical decline in neuroinflammatory and neurodegenerative diseases, for which there is an unmet therapeutic need. Here we reveal that efficient remyelination requires death of proinflammatory microglia followed by repopulation to a pro-regenerative state. We propose that impaired microglia death and/or repopulation may underpin dysregulated microglia activation in neurological diseases, and we reveal therapeutic targets to promote white matter regeneration.

Original languageEnglish
Pages (from-to)1046-1052
Number of pages7
JournalNature Neuroscience
Volume22
Issue number7
DOIs
Publication statusPublished - 10 Jul 2019

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    Lloyd, A. F., Davies, C. L., Holloway, R. K., Labrak, Y., Ireland, G., Carradori, D., Dillenburg, A., Borger, E., Soong, D., Richardson, J. C., Kuhlmann, T., Williams, A., Pollard, J. W., des Rieux, A., Priller, J., & Miron, V. E. (2019). Central nervous system regeneration is driven by microglia necroptosis and repopulation. Nature Neuroscience, 22(7), 1046-1052. https://doi.org/10.1038/s41593-019-0418-z