Central nervous system regeneration is driven by microglia necroptosis and repopulation

Amy F. Lloyd; Claire L. Davies; Rebecca K. Holloway; Yasmine Labrak; Graeme Ireland; Dario Carradori; Alessandra Dillenburg; Eva Borger; Daniel Soong; Jill C. Richardson; Tanja Kuhlmann; Anna Williams; Jeffrey W. Pollard; Anne des Rieux; Josef Priller; Veronique E. Miron

doi:10.1038/s41593-019-0418-z

Central nervous system regeneration is driven by microglia necroptosis and repopulation

Amy F. Lloyd, Claire L. Davies, Rebecca K. Holloway, Yasmine Labrak, Graeme Ireland, Dario Carradori, Alessandra Dillenburg, Eva Borger, Daniel Soong, Jill C. Richardson, Tanja Kuhlmann, Anna Williams, Jeffrey W. Pollard, Anne des Rieux, Josef Priller, Veronique E. Miron (Lead / Corresponding author)

Cell Signalling and Immunology

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Abstract

Failed regeneration of CNS myelin contributes to clinical decline in neuroinflammatory and neurodegenerative diseases, for which there is an unmet therapeutic need. Here we reveal that efficient remyelination requires death of proinflammatory microglia followed by repopulation to a pro-regenerative state. We propose that impaired microglia death and/or repopulation may underpin dysregulated microglia activation in neurological diseases, and we reveal therapeutic targets to promote white matter regeneration.

Original language	English
Pages (from-to)	1046-1052
Number of pages	7
Journal	Nature Neuroscience
Volume	22
Issue number	7
DOIs	https://doi.org/10.1038/s41593-019-0418-z
Publication status	Published - 10 Jul 2019

ASJC Scopus subject areas

General Neuroscience

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Author Accepted ManuscriptAccepted author manuscript, 1.82 MB

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Lloyd, A. F., Davies, C. L., Holloway, R. K., Labrak, Y., Ireland, G., Carradori, D., Dillenburg, A., Borger, E., Soong, D., Richardson, J. C., Kuhlmann, T., Williams, A., Pollard, J. W., des Rieux, A., Priller, J., & Miron, V. E. (2019). Central nervous system regeneration is driven by microglia necroptosis and repopulation. Nature Neuroscience, 22(7), 1046-1052. https://doi.org/10.1038/s41593-019-0418-z

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abstract = "Failed regeneration of CNS myelin contributes to clinical decline in neuroinflammatory and neurodegenerative diseases, for which there is an unmet therapeutic need. Here we reveal that efficient remyelination requires death of proinflammatory microglia followed by repopulation to a pro-regenerative state. We propose that impaired microglia death and/or repopulation may underpin dysregulated microglia activation in neurological diseases, and we reveal therapeutic targets to promote white matter regeneration.",

author = "Lloyd, {Amy F.} and Davies, {Claire L.} and Holloway, {Rebecca K.} and Yasmine Labrak and Graeme Ireland and Dario Carradori and Alessandra Dillenburg and Eva Borger and Daniel Soong and Richardson, {Jill C.} and Tanja Kuhlmann and Anna Williams and Pollard, {Jeffrey W.} and {des Rieux}, Anne and Josef Priller and Miron, {Veronique E.}",

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Lloyd, AF, Davies, CL, Holloway, RK, Labrak, Y, Ireland, G, Carradori, D, Dillenburg, A, Borger, E, Soong, D, Richardson, JC, Kuhlmann, T, Williams, A, Pollard, JW, des Rieux, A, Priller, J & Miron, VE 2019, 'Central nervous system regeneration is driven by microglia necroptosis and repopulation', Nature Neuroscience, vol. 22, no. 7, pp. 1046-1052. https://doi.org/10.1038/s41593-019-0418-z

TY - JOUR

T1 - Central nervous system regeneration is driven by microglia necroptosis and repopulation

AU - Lloyd, Amy F.

AU - Davies, Claire L.

AU - Holloway, Rebecca K.

AU - Labrak, Yasmine

AU - Ireland, Graeme

AU - Carradori, Dario

AU - Dillenburg, Alessandra

AU - Borger, Eva

AU - Soong, Daniel

AU - Richardson, Jill C.

AU - Kuhlmann, Tanja

AU - Williams, Anna

AU - Pollard, Jeffrey W.

AU - des Rieux, Anne

AU - Priller, Josef

AU - Miron, Veronique E.

PY - 2019/7/10

Y1 - 2019/7/10

N2 - Failed regeneration of CNS myelin contributes to clinical decline in neuroinflammatory and neurodegenerative diseases, for which there is an unmet therapeutic need. Here we reveal that efficient remyelination requires death of proinflammatory microglia followed by repopulation to a pro-regenerative state. We propose that impaired microglia death and/or repopulation may underpin dysregulated microglia activation in neurological diseases, and we reveal therapeutic targets to promote white matter regeneration.

AB - Failed regeneration of CNS myelin contributes to clinical decline in neuroinflammatory and neurodegenerative diseases, for which there is an unmet therapeutic need. Here we reveal that efficient remyelination requires death of proinflammatory microglia followed by repopulation to a pro-regenerative state. We propose that impaired microglia death and/or repopulation may underpin dysregulated microglia activation in neurological diseases, and we reveal therapeutic targets to promote white matter regeneration.

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DO - 10.1038/s41593-019-0418-z

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C2 - 31182869

AN - SCOPUS:85067233115

SN - 1097-6256

VL - 22

SP - 1046

EP - 1052

JO - Nature Neuroscience

JF - Nature Neuroscience

IS - 7

ER -

Central nervous system regeneration is driven by microglia necroptosis and repopulation

Abstract

ASJC Scopus subject areas

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